Associate Director, Precision Medicine

Position Summary

Leads the development and implementation of the Model-Informed Drug Development (MIDD) strategy for drugs and other therapeutic agents in clinical development, in partnership with Clinical Pharmacology (CP) and other quantitative functions. This role places quantitative evidence at the center of development and regulatory decision-making.

MIDD advances drug development by integrating diverse data through pharmacometric (PMx) models to inform development decisions and regulatory assessments. Model-Based Meta-Analysis (MBMA) provides a quantitative assessment of competitors and comparators to further refine asset strategy. MIDD informs dose and regimen selection, clinical study hypotheses, and the overall clinical data package supporting regulatory assessment of clinical pharmacology and benefit-risk. PMx analyses may also influence regulatory approval decisions and, in some cases, serve as a primary basis for approval.

Key Responsibilities

• Partner with the Clinical Pharmacology lead to develop the MIDD strategy and define the PMx plan for assigned assets.
• Lead integration across quantitative disciplines to develop and execute a coherent modeling and data strategy.
• Lead the planning, execution, interpretation, and reporting of formal PMx analyses supporting clinical study reports (CSRs), health authority submissions, and responses to regulatory questions.
• Translate complex modeling results into clear, actionable recommendations that inform asset strategy, development plans, and governance decisions.
• Serve as the MIDD subject matter expert, partnering with Clinical Pharmacology and other quantitative functions to influence development decisions for therapeutic agents.
• Advance PMx infrastructure, tools, methodologies, and ways of working.
• Lead PMx and cross-functional initiatives that strengthen quantitative decision-making across development programs.
• Provide scientific direction and oversight for PMx analyses conducted by external vendors.
• Represent the MIDD strategy and provide subject matter expertise in interactions with health authorities, helping to inform regulatory strategy.
• Collaborate with internal and external subject matter experts to advance MIDD methodologies and capabilities and introduce innovative quantitative approaches into development programs.
• Provide scientific guidance and mentorship to junior scientists in PMx and MIDD.

Qualifications & Experience

• Advanced degree in a relevant scientific or quantitative field, such as an MS, PhD, or PharmD.
• 5+ years of relevant experience with demonstrated progression in pharmacometrics and Clinical Pharmacology knowledge and increasing scientific impact.
• Demonstrated expertise in quantitative data analysis, data wrangling and transformation, visualization, population pharmacokinetic (PPK) modeling, and exposure-response (E-R) modeling.
• Proficiency with relevant modeling and programming tools, such as R, NONMEM, Monolix, Pumas, MATLAB, Python, and/or Julia.
• Working knowledge of the drug development process and the application of quantitative evidence to development and regulatory decision-making.
• Experience with mechanistic modeling approaches, such as Quantitative Systems Pharmacology (QSP) and Physiologically Based Pharmacokinetic (PBPK) modeling, is preferred.
• In-depth knowledge of current practices, methodologies, and emerging issues in pharmacometrics and Clinical Pharmacology, with a demonstrated interest in advancing the field.
• Strong written and verbal communication skills, with the ability to influence stakeholders and deliver compelling scientific presentations.
• Demonstrated ability to translate complex modeling results into clear recommendations that influence cross-functional decisions.
• Proven ability to drive scientific impact in a dynamic, collaborative, and team-oriented environment.

• #LI-Hybrid
• We hire for skills and capabilities, not just credentials - if this role excites you, but doesn't perfectly match your resume, we encourage you to apply anyway.

Compensation Overview

Cambridge Crossing: $209,250 - $253,565

The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully - carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

Benefits

Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans - including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).

• U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.
• Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays.

Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs. Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day.

How We Work

• Where you work matters - because collaboration, innovation and patient impact happen in many settings.
• Our roles are structured across four work models: site-essential, site-by-design, field-based and remote-by-design.
• The model assigned to this role is based on its core responsibilities.

Data Protection

• We will never request payments, financial information, or social security numbers during our application or recruitment process.
• Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

• If this posting is missing required information required by local law or incorrect, contact BMS at with the Job Title and Requisition number.
• Do not send application-related inquiries to this email.
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R1608260: Associate Director, Precision Medicine