AVP, Oncology Pharmacology

Position Summary

As the Oncology Pharmacology senior leader, you will lead a dynamic group of scientists conducting research to identify medicines that effectively treat various forms of cancer. You will oversee several portfolio projects simultaneously and be responsible for the ultimate delivery of clinical candidates.

As part of the portfolio leadership team, you will guide the strategic focus of our Oncology portfolio to balance delivery of medicines with the innovation necessary for next-generation, differentiated products across various modalities, including small and large molecules. As the pharmacology leader, you will integrate cross-functional information to set program priorities, portfolio decisions, and innovation.

You will lead a team of project leaders, senior scientists, and junior scientists to ensure efficient program execution and decision making and mentor the next generation of scientific and project leaders.

Working with peer leaders and project teams, you will regularly update senior leadership and engage with clinical colleagues to guide target product profile (TPP) alignment and product differentiation to ensure our best medicines advance into clinical development. Collaboration across functional areas within Lilly is required.

You will continue to build strong relationships with colleagues in Indianapolis and at other sites including CMC, toxicology, and clinical departments to strengthen collaborations key to our discovery program success. You will be a key member of the Oncology organization, responsible for maintaining its scientific quality and efficiency and helping guide the company's strategic direction.

Scientific roles and responsibilities

• Oversee several teams of scientists who lead individual portfolio programs and actively mentor our next-generation project leaders.
• Synthesize complex, cross-functional information, including target biology, clinical opportunity, product differentiation, and competitive landscape to support our Oncology strategy and portfolio priorities.
• Serve as a key member of the Oncology portfolio leadership team, working with peer leaders in New York and South San Francisco to execute our pipeline strategy and advance molecules from early Discovery to IND.
• Collaborate with cross-functional teams across Lilly to drive the execution of Oncology programs. For example, work with project teams across functions and sites to provide the expertise, resources, and infrastructure to efficiently progress all Oncology candidates.
• Integrate newly acquired technologies and scientific teams into our portfolio projects to deliver differentiated, innovative medicines.
• Oversee the design and execution of key mechanistic and preclinical experiments involving diverse oncogenic mechanisms (e.g., oncogenic signaling pathways, tumor-specific targets, biologic mechanisms of tumor inhibition) across multiple tumor indications.
• Contribute to business development strategy and recommend novel modalities, targets, and platforms that add value to our existing Oncology portfolio. Contribute to the assessment of external opportunities, formal diligence, and recommendations to leadership.
• Assemble documents and present at leadership meetings (including Discovery portfolio reviews, Clinical review meetings, and Candidate advancement reviews).
• Deliver IND sections related to preclinical development as well as supporting preclinical reports.
• Partner with Translational and Clinical colleagues to define biomarker, patient selection and indication strategy, and to develop PK/PD-based dose projections, so preclinical data packages support first-in-human readiness and the TPP.

Leadership roles and responsibilities

• Lead, coach, develop, and manage teams of project leaders and scientists
• Liaise with internal teams and provide guidance on key strategic business decisions
• Build and execute on roadmaps that deliver on specific targets and overall strategic projects
• Align with senior leaders around portfolio decisions, priorities, and resources
• Cross-site leadership: Lead and influence across sites, aligning INDY, NYC and SSF teams on shared priorities and ways of working.
• Talent development: Develop project leaders and future scientific leaders, and foster an inclusive, high-performing team culture.
• Support and communicate difficult portfolio decisions, including stopping/prioritizing programs, using data-driven criteria and a transparent rationale.

Minimum Qualifications

• PhD in pharmacology, cancer cell biology, or allied disciplines with a minimum of 15 years' experience (at least 10 years of direct drug development experience)

Additional Preferences

• Demonstrated success in developing Oncology medicines across modalities (experience in large molecules including ADCs desired but not required)
• Experience in IND submission and preclinical data package generation
• Hands-on, direct drug-hunting experience with a track record of progressing multiple programs to Phase 1
• Ability to collaborate with translational functions (PK/PD, toxicology, antibody discovery)
• Deep understanding of drug discovery and development through Phase 1 (or beyond)
• Proven success leading, managing, and coaching large cross-functional teams in dynamic organizations
• Demonstrated ability and track record in overseeing work performed by third parties/vendors/strategic partners
• Demonstrated experience working collaboratively across scientific disciplines to meet business goals
• Demonstrated business acumen
• Demonstrated excellence in making key strategic decisions in support of broader business goals
• Excellent written and verbal communication skills

Physical Demands/Travel: TBD; estimated ~20%

Additional Information: The successful candidate for this position will transfer laterally into the role at their current level. For example, an R9 employee who applies for and is selected for this position, posted as R10, would transfer laterally at the R9 level. level.

Work Environment: You will work in our state-of-the-art laboratories in our Indianapolis headquarters facility.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women's Initiative for Leading at Lilly (WILL).

• Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $219,000 - $321,200
• Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance).

In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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