Bioinformatics Research Analyst - Neurology

About the role

• Location
• ST. LOUIS, MO 63108
• Scheduled Hours
• 40

Position Summary

Provides critically complex research and experimentation for department/s allowing the advancement of scientific analysis and discovery. Serves as a subject matter expert offering support, training and guidance relative to the discipline/area. May participate and/or present on the research developed, or the established work of those within the department.

The Pottier Laboratory in the Department of Neurology at Washington University School of Medicine is recruiting a Bioinformatician to join our research on the genetics and transcriptomics of Alzheimer disease, frontotemporal dementia and related neurodegenerative disorders. The position focuses on single-nuclei RNA sequencing (snRNA-seq) of human brain, with additional work in whole-genome sequencing (short- and long-read).

You will work closely with the PI, postdocs, other computational scientists and clinical and neuropathology collaborators as part of the NeuroGenomics and Informatics (NGI) Center, a group of more than 20 computational and statistical researchers.

Primary Duties & Responsibilities

• Implements: Algorithms and computer software for analyzing omics-based data sets [high-throughput, massively parallel genomic/proteomic/clinical]; Data management and analysis solutions that aid in the storage, investigation and dissemination of large data sets.
• Coordinates research project with other investigators and institutions.
• Participates in developing hypotheses and experimental design.
• Assists with reporting of methods, data and results.
• Process and analyze short- and long-read snRNA-seq data, including QC, clustering, cell-type annotation, differential expression and isoform-level analyses.
• Process and analyze short- and long-read WGS data, including QC, variant calling, structural variants and association analyses.
• Integrate transcriptomic and genetic data with clinical, neuropathological and proteomic data.
• Develop, maintain and improve reproducible pipelines on high-performance computing systems as data and tools change.
• Organize, back up and share data with collaborators and consortia.
• Advise team members and train and supervise junior scientists.
• Participate in lab and collaborator meetings.
• Contribute to manuscripts, grants and reports, including methods, results and figures.

Job Location/Working Conditions

• Works in a laboratory environment with potential exposure to biological and chemical hazards
• Must be physically able to wear protective equipment and to provide standard care to research animals
• Normal office environment.

Physical Effort

• Typically sitting at desk or table.
• Repetitive wrist, hand or finger movement (PC Typing).

Equipment

• Office equipment.

Additional information

The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.

Required Qualifications

Education

Bachelor's degree or combination of education and/or experience may substitute for minimum education.

Certifications /Professional Licenses

• No specific certification/professional license is required for this position.
• Work Experience: Relevant Experience (2 Years)

Skills: Not Applicable

Driver's License: A driver's license is not required for this position.

More About This Job

WashU seeks highly motivated individuals who are able to perform duties in a manner consistent with our core mission and guiding principles.

Preferred Qualifications

Education: Master's degree

Certifications /Professional Licenses

No additional certification/professional licenses unless stated elsewhere in the job posting.

Work Experience

No additional work experience unless stated elsewhere in the job posting.

Skills

• Analytical Thinking, Bioinformatics Tools, Communication, Complex Data Analysis, Computational Biology, Critical Reasoning, Gene Expression Microarray, Genome Sequencing, Group Problem Solving, Human Genetics, Model Organism
• Grade
• R09

Salary Range $41,700.00 - $75,600.00 / Annually

The salary range reflects base salaries paid for positions in a given job grade across the University. Individual rates within the range will be determined by factors including one's qualifications and performance, equity with others in the department, market rates for positions within the same grade and department budget.

Questions

For frequently asked questions about the application process, please refer to our External Applicant FAQ.

Accommodation

If you are unable to use our online application system and would like an accommodation, please email or call the dedicated accommodation inquiry number at and leave a voicemail with the nature of your request.

Pre-Employment Screening

All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.

Benefits Statement

Personal

• Up to 22 days of vacation, 10 recognized holidays, and sick time.
• Competitive health insurance packages with priority appointments and lower copays/coinsurance.
• Take advantage of our free Metro transit U-Pass for eligible employees.
• WashU provides eligible employees with a defined contribution (403(b)) Retirement Savings Plan, which combines employee contributions and university contributions starting at 7%.

Wellness

• Wellness challenges, annual health screenings, mental health resources, mindfulness programs and courses, employee assistance program (EAP), financial resources, access to dietitians, and more!

Family

• We offer 4 weeks of caregiver leave to bond with your new child. Family care resources are also available for your continued childcare needs. Need adult care? We've got you covered.
• WashU covers the cost of tuition for you and your family, including dependent undergraduate-level college tuition up to 100% at WashU and 40% elsewhere after seven years with us.