Clinical Biomarkers Lead
- Pay
- $187,200 – $200,000 per year
- Location
- Watertown, MA · On-site
- Job type
- Full-time
- Level
- Lead / Staff
- Experience
- 4+ years
- Education
- Doctorate
- Listed
- 31 days ago
Skills & highlights for this role
- assay transfer and validation
- flow cytometry
- immunohistochemistry
- next-generation sequencing
- CRO oversight
Also useful
- proteomics
- ligand binding assays
- companion diagnostic development
Biomarker Lead
The Biomarker Lead will be accountable for biomarker planning and execution across one to two clinical programs, with a focus on programs approaching or in the clinic. This includes designing biomarker plans for each program, identifying appropriate bioassay labs/CROs, managing assay transfer and validation studies, and ensuring biomarker data are ingested, tracked, QCed, and integrated efficiently.
The successful candidate will serve as the central point of accountability for biomarkers for their program, enabling high-quality and timely data delivery that supports Treeline's mission to advance precision medicine.
Responsibilities
- Develop and oversee biomarker plans for each clinical protocol.
- Identify and qualify bioassay labs/CROs for biomarker assays
- Lead assay transfer from Translation biology teams to bioassay labs/CROs, ensuring validation and qualification.
- Oversee testing at bioassay labs/CROs, ensuring quality, compliance, and adherence to protocol requirements.
- Collaborate with Clinical Development, Clinical Operations, Translational Biology, Data Management, Biostatistics, and Regulatory to ensure biomarker deliverables align with clinical program needs.
- Provide updates on biomarkers to internal stakeholders.
- Work with Translational Biology and Clinical Development colleagues to analyze biomarker data and test key program hypotheses.
Qualifications
- PhD with postdoctoral training in Life Sciences, Cell Biology, Molecular Biology, Immunology, or a related field.
- 4-5 years of industry experience in a clinical setting, in clinical biomarkers, translational medicine, or a related function within biotech/pharma.
- Proven expertise in assay transfer, validation, and qualification with CRO and lab oversight experience.
- Knowledge of biomarker assay platforms (flow cytometry, IHC, NGS, proteomics, ligand binding assays) and their clinical application.
- Excellent organizational, cross-functional leadership, and communication skills, with the ability to manage multiple workstreams across one to two programs in a fast-paced environment.
- Oncology experience strongly preferred. Immunology and/or neuroscience experience considered upside.
- Experience with development of companion diagnostics (CDx) considered a plus.
Pay and benefits
This position is classified as exempt. The anticipated annual base salary range for candidates who will work in Watertown is $187,200 - $200,000. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.
Equal opportunity and legal notices
Please be aware of recruitment fraud and related job scams, where scammers present themselves as recruiters but are seeking to steal money or personal information. Keep the following in mind to protect yourself:
- Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline.
- We do not conduct interviews through RingCentral, Skype or Telegram.
- Our job openings are first posted to treeline.bio/careers. If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website.
- You can find more information about job scams at consumer.ftc.gov/articles/job-scams.
- To report job scams, head to ReportFraud.ftc.gov.
Notice to Search Firms/Third-Party Recruitment Agencies
The Human Resources team manages the recruitment and employment process for Treeline Biosciences. To protect the interests of all parties involved, Treeline Biosciences will only accept resumes from a recruiter if an executed search agreement directed to the particular position or positions is in place at the start of the recruitment effort.
Unsolicited resumes sent to Treeline Biosciences from recruiters do not constitute any type of relationship between the recruiter and Treeline Biosciences and do not obligate Treeline Biosciences in any way to pay fees should we hire from those resumes. Recruiters are requested not to contact or present candidates directly to our hiring manager or employees.
From Treeline Biosciences's careers page, first listed on Rolev.ai on October 10, 2026. Rolev.ai is not the employer.
How Rolev.ai helps with this application
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Common questions
What is the salary for the Clinical Biomarkers Lead role at Treeline Biosciences?
The Clinical Biomarkers Lead posting at Treeline Biosciences states compensation of $187,200 – $200,000 per year. It is listed as a full-time position. Final pay may depend on location, experience, and interview evaluation on Treeline Biosciences's official career site.
Where is the Clinical Biomarkers Lead job at Treeline Biosciences located?
This Clinical Biomarkers Lead position at Treeline Biosciences is located in Watertown, MA (On-site). Always check Treeline Biosciences's application page for specific state eligibility or relocation policies.
What qualifications are required for Clinical Biomarkers Lead at Treeline Biosciences?
For the Clinical Biomarkers Lead role, Treeline Biosciences highlights 4+ years of relevant experience; a doctorate; experience with assay transfer and validation, flow cytometry, immunohistochemistry, next-generation sequencing, CRO oversight. Rolev.ai can score your existing resume against these requirements and show any skill gaps before you apply.
How do I apply for the Clinical Biomarkers Lead position at Treeline Biosciences?
This listing links directly to Treeline Biosciences's Greenhouse application page. You can apply directly on Treeline Biosciences's site, or use Rolev.ai to check your resume fit, generate a zero-hallucination tailored resume and cover letter for this posting, and autofill the Greenhouse application form in 1 click with the Rolev.ai Chrome extension. You always review the form and press Submit yourself.