Prolaio
Healthcare & Life SciencesDirect Greenhouse career site

Data Architect, Clinical

Pay
$148,000 per year
Location
Chicago, IL · On-site
Job type
Full-time
Level
Director
Experience
10+ years
Education
Bachelor's degree
Listed
30 days ago

Skills & highlights for this role

  • healthcare data platforms
  • data modeling
  • HL7 and FHIR
  • SQL and Python

Also useful

  • Snowflake
  • Databricks
  • dbt
  • Airflow

Stated benefits & perks

  • Medical
  • Dental
  • Vision
  • 401k
  • Parental leave

Who Are We?

Prolaio believes that continuous learning and collaboration can make a significant difference in how heart care is administered. We are creating smarter ways to address heart disease and heart risks by uniting patients, care teams, and researchers on a secure, technology-enabled platform that drives clinical innovation and offers a path towards better patient outcomes.

This is precision cardiology, and we know it's within reach.

The Overview

The Data Architect will shape the backbone of Prolaio's healthcare data ecosystem, defining and scaling the architectures that power clinical intelligence products, real-world data pipelines, analytics, data science, clinical operations, quality, and other enterprise use cases in a regulated environment. In this role, you turn complex clinical and operational data into interoperable, trustworthy, and scalable platforms that enable Prolaio to transform continuous, predictive, and shareable heart data into faster therapeutic discovery and better cardiovascular outcomes.

This role is ideal for a self-starter with deep healthcare data experience who wants to architect modern platforms across structured, semi-structured, and unstructured data, embedding lifecycle management, standardization, lineage, provenance, compliance, and AI enablement into the foundation of Prolaio's data ecosystem.

The Specifics

  • Define the target-state data architecture and roadmap for Prolaio's regulated healthcare data platform in support of product, analytics, data science, data services, clinical operations, and quality use cases.
  • Architect scalable, secure, and interoperable data platforms that support structured, semi-structured, and unstructured data across clinical, operational, device, and patient-generated sources relevant to Prolaio's cardiovascular and research mission.
  • Lead architecture decisions for storage, compute, orchestration, metadata, APIs, and integration patterns across cloud-native environments and modern data platforms.
  • Establish architecture standards and reference patterns that support reliability, performance, extensibility, and validated operation in regulated settings.
  • Design and govern conceptual, logical, and physical data models for clinical trials, cardiovascular and physiological data, real-world data, claims, medication, socio-economic, behavioral, and related healthcare datasets.
  • Apply healthcare terminologies, ontologies, and common data models where appropriate, including standards such as HL7, FHIR, ICD, SNOMED CT, LOINC, RxNorm, OMOP, and CDISC.
  • Lead efforts to standardize and normalize disparate data sources into governed, reusable, analysis-ready datasets suitable for regulated workflows, clinical research, and product development.
  • Architect end-to-end data flows and reusable pipelines for ingestion, validation, transformation, enrichment, publishing, retention, archival, and decommissioning across batch, streaming, and hybrid workloads.
  • Define and implement data lifecycle management practices that support retention, access control, traceability, reproducibility, lineage, provenance, and auditability in regulated healthcare environments.
  • Design data architectures that enable AI, analytics, and machine learning use cases by supporting feature generation, retrieval workflows, governed access, and production deployment needs.

Who You Are?

  • Bachelor's degree in computer science, Data Engineering, Information Systems, Biomedical Informatics, Engineering, or a related field.
  • Minimum 10 years of experience in healthcare, life sciences, medtech, digital health, or other patient-data-focused environments, including at least 5 years in clinical data, real-world data, clinical trials data, or other patient-centered data platforms.
  • Demonstrated experience architecting healthcare data platforms that support structured, semi-structured, and unstructured data in regulated or validated environments.
  • Deep understanding of data from cardiology focused wearables devices, claims, socioeconomic, behavioral, and EHR.
  • Deep understanding of healthcare data domains, data modeling, standardization, normalization, and the application of healthcare terminologies and common data models.
  • Strong experience working in a cross-functional, matrixed organization and partnering effectively with Product, Engineering, Data Science, Analytics, Clinical Operations, Quality, and Security teams, with the ability to operate as a self-starter in a growth-stage environment.
  • Strong familiarity with cloud platforms such as GCP, AWS, or Azure and modern data platforms such as Snowflake, Databricks, BigQuery, Redshift, Synapse, or comparable environments.
  • Experience with ETL or ELT, orchestration, and large-scale data processing tools such as dbt, Airflow, Dagster, Spark, Kafka, Fivetran, Informatica, Talend, or similar technologies.
  • Strong SQL and Python skills, with familiarity in APIs, event-driven architectures, interoperability frameworks, and clinical data exchange patterns such as HL7 and FHIR
  • Familiarity with metadata, lineage, catalog, governance, and AI-enablement tools, including platforms for semantic indexing, vectorization, retrieval, and data lifecycle automation.

Why Prolaio?

  • Impactful Work: You will join in the fight against heart failure (HF) and hypertrophic cardiomyopathy (HCM) with the goal of extending and saving the lives of our patients while also being at the forefront of changing the healthcare industry through technology.
  • Innovative Environment: You will be part of an organization doing something that's never been done before.
  • Professional Growth: You will join a growing team and have a substantial impact on our daily and future operations with the opportunity to continuously learn and grow.
  • Collaborative Team: You will be part of a team of collaborative, curious, and committed individuals focused on the collective good, inclusiveness, scientific excellence, and advancing digital health for cardiology.

Why You'll Love Working Here

  • Meaningful Compensation: Competitive salary, performance bonus, and equity so you can share in what we build.
  • Great Health Coverage: Medical, dental, and vision plans with multiple options and strong company contributions.
  • Flexible Spending Perks: HSA, FSA, commuter benefits, and a $1,200 annual Lifestyle Spending Account to support wellness, commuting, family needs, and more.
  • Time to Recharge: Generous paid time off, sick leave, and company holidays.
  • Family-First Benefits: Paid parental leave, caregiver leave, and support for growing families.
  • Security & Peace of Mind: Company-paid life insurance and short- and long-term disability coverage.
  • Plan for the Future: 401(k) plan to help you build long-term financial security.
  • Care When You Need It: Easy access to telehealth and optional supplemental coverage for life's unexpected moments.

Starting Salary is at $148,000.00 (Exact Compensation may vary based on skills, experience, and location)

Read the original posting

From Prolaio's careers page, first listed on Rolev.ai on October 10, 2026. Rolev.ai is not the employer.

How Rolev.ai helps with this application

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Common questions

What is the salary for the Data Architect, Clinical role at Prolaio?

The Data Architect, Clinical posting at Prolaio states compensation of $148,000 per year. It is listed as a full-time position. Final pay may depend on location, experience, and interview evaluation on Prolaio's official career site.

Where is the Data Architect, Clinical job at Prolaio located?

This Data Architect, Clinical position at Prolaio is located in Chicago, IL (On-site). Always check Prolaio's application page for specific state eligibility or relocation policies.

What qualifications are required for Data Architect, Clinical at Prolaio?

For the Data Architect, Clinical role, Prolaio highlights 10+ years of relevant experience; a bachelor's degree; experience with healthcare data platforms, data modeling, HL7 and FHIR, SQL and Python. Rolev.ai can score your existing resume against these requirements and show any skill gaps before you apply.

How do I apply for the Data Architect, Clinical position at Prolaio?

This listing links directly to Prolaio's Greenhouse application page. You can apply directly on Prolaio's site, or use Rolev.ai to check your resume fit, generate a zero-hallucination tailored resume and cover letter for this posting, and autofill the Greenhouse application form in 1 click with the Rolev.ai Chrome extension. You always review the form and press Submit yourself.