Distinguished Scientist, Systems Toxicology

About the role

• Location: Cambridge, MA; Morristown, NJ

About the Job

As Distinguished Scientist, Systems Toxicology, you will provide scientific leadership in the application of multi-omics datasets and systems biology to predict safety liabilities, investigate mechanisms of toxicity, and assess human relevance. You will connect complex molecular and phenotypic datasets to generate testable hypotheses, guide experimental investigations, and inform decisions across drug discovery and development. Strong knowledge of regulatory safety requirements in the field of pharmaceutical drug development is also necessary. Natural strengths in networking and communication are also essential.

Within Toxicology Innovation, you will shape the scientific direction of omics-based safety assessment and lead the development of robust analytical workflows. Working across Toxicology Innovation, and in partnership with project toxicology and scientific advisors, you will translate biological questions into integrated analyses and actionable scientific insights.

This is a senior, hands-on individual contributor position with global scientific influence. You will lead complex investigations, establish analytical approaches and standards, mentor scientists across disciplines, and build capabilities that strengthen safety assessment across the portfolio.

Sanofi's Preclinical Safety department is a global, science-driven organization committed to delivering innovative, data-informed safety assessments that support the development of life-changing medicines. The Global Toxicology Innovation group sits at the intersection of computational science, biology, and drug development - pioneering new approaches to toxicity prediction, mechanistic understanding, and clinical translatability.

Join the engine of Sanofi's mission - where deep immunoscience meets bold, AI-powered research. In R&D, you'll drive breakthroughs that could turn the impossible into possible for millions.

Main responsibilities

• Provide scientific direction for systems toxicology, defining approaches for applying omics and integrative biology to priority safety questions.
• Lead integrated analyses of complex biological datasets, connecting transcriptomics with complementary data such as proteomics, metabolomics, imaging, pathology, and functional assays.
• Generate and prioritize mechanistic hypotheses using pathway analysis, network biology, molecular signatures, and existing biological knowledge.
• Establish reproducible and scalable analytical workflows, spanning data processing, quality assessment, statistical analysis, visualization, and reporting.
• Drive cross-functional investigations across Preclinical Safety, connecting early screening, complex models, and investigative studies with molecular mechanisms.
• Provide scientific leadership across project teams and global functions, working with project toxicologists and scientific advisors to define decision-relevant questions and communicate integrated findings.
• Demonstrate scientific and portfolio impact, serving as a scientific authority and mentor across the global organization.

About You

To succeed in this role, you will bring a rare combination of deep expertise in systems biology and omics, strong toxicological judgement, and a sustained record of translating complex data into mechanistic understanding and meaningful project impact. You combine scientific independence with hands-on analytical capability and the ability to build productive partnerships across disciplines.

• Minimum Requirements: MS plus 8 years experience or PhD plus 5 years experience
• Scientific expertise: Systems Biology, Computational Biology, Bioinformatics, or a related discipline, with extensive research experience and demonstrated independent leadership of complex investigations.
• Technical skills: Deep hands-on expertise in transcriptomics and demonstrated experience integrating multiple molecular or phenotypic data types.
• Computational and statistical capabilities: Strong proficiency in R and/or Python and relevant bioinformatics tools.
• Mechanistic and translational interpretation: Expertise in pathway and network analysis, molecular signatures, and hypothesis generation.
• Drug discovery and safety experience: Substantial experience applying systems approaches to toxicology, safety assessment, or closely related mechanistic research in pharmaceutical or biotechnology settings.
• Strategic mindset: Understanding of how preclinical safety data translates to human safety, ability to translate scientific vision into actionable roadmaps, connect digital toxicology to broader R&D strategy.
• Communication & influence: Ability to communicate complex analyses clearly to experimental scientists, computational specialists, project teams, and senior leaders.

Why Choose Us

• Bring the miracles of science to life alongside a supportive, future-focused team.
• Discover endless opportunities to grow your talent and drive your career, whether it's through a promotion or lateral move, at home or internationally.
• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks' gender-neutral parental leave.
• Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs.
• Help improve the lives of millions of people globally by making drug development quicker and more effective.
• Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science.
• #GD-SA
• #LI-SA
• #vhd
• #LI-Hybrid
• Pursue progress, discover extraordinary

Additional information

Better is out there. Better medications, better outcomes, better science. But progress doesn't happen without people - people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let's be those people.

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Pay and benefits

The salary range for this position is: $178,500.00 - $257,833.33

All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.