Lead Security & Infrastructure Engineer
- Pay
- $160,000 – $220,000 per year
- Location
- South San Francisco, CA · On-site
- Job type
- Full-time
- Level
- Lead / Staff
- Experience
- 4+ years
- Listed
- 30 days ago
Skills & highlights for this role
- identity and access management
- MDM
- AWS
- phishing-resistant MFA
- incident response
Also useful
- GxP
- scripting
- LLM governance
Stated benefits & perks
- Health
- Dental
- Vision
- 401k match
- Pto 20 days
Position
We're hiring our first dedicated IT lead to own the systems, infrastructure, and security that keep NewLimit running as we grow from to more than 100 people over the next two years. This is a hands-on individual contributor role with broad ownership: you'll set technical direction, decide what we build, buy, automate, or outsource, and jump in yourself when that's the fastest path. An MSP handles routine helpdesk, provisioning, and onboarding/offboarding, so you can focus on the most critical strategic work that requires judgment.
Your scope will span identity and access, endpoints, office and lab infrastructure, security, SaaS systems, and a shared stake in cloud and data infrastructure. You'll help us scale these systems as we enter first-in-human studies and expand clinical, manufacturing, and sponsor-facing operations-raising the bar on security, reliability, data integrity, and audit readiness without burying a fast-moving biotech in process.
We care more about slope than intercept. You've owned real systems, learn unfamiliar domains quickly, and would rather automate a recurring problem than file another ticket. You'll sit within Computational Sciences alongside computational biologists and software and ML engineers who will help with hard problems and expect the same from you.
What you'll do
- Own identity, access, and endpoint standards across Google Workspace, AWS, GitHub, and our macOS/Windows fleet: least privilege, phishing-resistant MFA, SSO, device compliance, and lifecycle automation.
- Lead our MSP and technical vendor relationships day to day: scope, SLAs, escalations, renewals, and performance. Help decide what we build, buy, outsource, or bring in-house.
- Run security operations at our scale, including monitoring, incident response, tabletop exercises, and post-incident reviews, working with MDR/IR partners where they add leverage.
- Own network and office/lab infrastructure (connectivity, backups, continuity), and partner with the team on cloud and data infrastructure: AWS account structure and security and integrations between systems (lab instruments, HRIS, finance, ELN/LIMS).
- Help build the tooling and policies that make all of this scale: onboarding and access-review automation, security reporting, LLM/agent governance, data classification, software approval, and acceptable-use standards.
Requirements
- 4+ years in IT, infrastructure, or security, including experience as a primary or sole IT/security owner at a small company and managing MSPs or technical vendors.
- Working fluency across identity, MDM, networking, AWS fundamentals, Google Workspace or M365 administration, backups, and SaaS administration.
- You script well enough to automate your own work, move data between systems, and comfortably read someone else's code.
- Strong practical security judgment: you know how to right-size controls for company stage and how expectations change as sponsors, auditors, and regulated workflows enter the picture.
- You already use LLMs and agents to work more effectively, understand how to use them safely, and communicate clearly with scientists, executives, vendors, and auditors.
Nice to haves
- Exposure to GxP, clinical, or other regulated environments, or SOC 2 / ISO 27001 readiness.
- Familiarity with regulated-data expectations (e.g., audit trails, ALCOA+).
- Data engineering experience: pipelines, ETL/ELT, warehouse fundamentals.
- Experience supporting lab environments where instruments, data movement, and uptime matter.
Benefits
- Health, dental, and vision insurance
- 401(k) with company match
- Industry-leading paid time off (PTO), 20 days/year for all employees plus holidays
- Paid parental leave
- Meals and snacks on-site
Salary Range
$160,000 to $220,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO.
About NewLimit
NewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.
From NewLimit's careers page, first listed on Rolev.ai on October 10, 2026. Rolev.ai is not the employer.
How Rolev.ai helps with this application
Rolev.ai is a job search and application tool for US job seekers. For this Lead Security & Infrastructure Engineer role at NewLimit, it shows how your resume fits, tailors your resume to the posting, and prepares the application for you to review.
See how you fit
Openings from employer career sites are ranked against your whole resume—and searchable inside Claude, ChatGPT, and Cursor via Rolev.ai MCP.
Tailor without inventing
Every change to your resume is checked against your original. New experience goes in only with your yes—zero fabricated claims.
Draft the full kit
Tailored and Full Match resumes, role-specific cover letters, and answers to employer screening questions are prepared in seconds.
1-Click Extension Autofill
The Chrome extension fills the employer's Greenhouse, Workday, Lever, or Ashby form in 1 click. You review it and press Submit.
Similar roles
All Information Security Engineer jobs- Associate, Information Security EngineerING · New York City, NY
- Zero Trust Technical LeadCACI · Mclean, VA
- Cyber Systems Engineer - Level 3 or 4 (AHT)Ngc · Aurora, CO · $125k – $188k/yr
- Sr. Cybersecurity Engineer (ISSE)Applied IS · Huntsville, AL
- Principal Identity & Access Management (IAM) EngineerEarly Warning · Chicago, IL
- Lead InfoSec Engineer, Vulnerability ManagementSpgi · New York, NY · $125k – $145k/yr
Common questions
What is the salary for the Lead Security & Infrastructure Engineer role at NewLimit?
The Lead Security & Infrastructure Engineer posting at NewLimit states compensation of $160,000 – $220,000 per year. It is listed as a full-time position. Final pay may depend on location, experience, and interview evaluation on NewLimit's official career site.
Where is the Lead Security & Infrastructure Engineer job at NewLimit located?
This Lead Security & Infrastructure Engineer position at NewLimit is located in South San Francisco, CA (On-site). Always check NewLimit's application page for specific state eligibility or relocation policies.
What qualifications are required for Lead Security & Infrastructure Engineer at NewLimit?
For the Lead Security & Infrastructure Engineer role, NewLimit highlights 4+ years of relevant experience; experience with identity and access management, MDM, AWS, phishing-resistant MFA, incident response. Rolev.ai can score your existing resume against these requirements and show any skill gaps before you apply.
How do I apply for the Lead Security & Infrastructure Engineer position at NewLimit?
This listing links directly to NewLimit's Greenhouse application page. You can apply directly on NewLimit's site, or use Rolev.ai to check your resume fit, generate a zero-hallucination tailored resume and cover letter for this posting, and autofill the Greenhouse application form in 1 click with the Rolev.ai Chrome extension. You always review the form and press Submit yourself.