Manufacturing Associate II, Oligo

How you will make an impact

• Review production schedules, interpret manufacturing specifications, calculate material requirements, and coordinate resources to ensure timely execution of production activities.
• Prepare manufacturing areas, equipment, and materials for cGMP production activities, including project initiation and changeovers.
• Execute manufacturing processes in accordance with approved standard operating procedures (SOPs), batch records, and cGMP requirements.
• Accurately complete batch records, production logs, equipment records, and other required documentation in compliance with Good Documentation Practices (GDP).
• Operate, maintain, and troubleshoot manufacturing equipment, perform routine preventive maintenance, and coordinate repairs as needed.
• Author, review, revise, and execute batch records, SOPs, and other controlled manufacturing documents.
• Train, mentor, and provide technical guidance to manufacturing personnel, ensuring adherence to established procedures, quality standards, and production timelines.
• Support onboarding, qualification, and implementation of new manufacturing equipment and processes with minimal supervision.
• Identify and troubleshoot manufacturing process issues, evaluate production bottlenecks, and implement continuous improvement initiatives to enhance operational efficiency and product quality.
• Collaborate with Process Development, Quality, Engineering, and other cross-functional teams to support production requirements, process transfers, and manufacturing improvements.
• Provide timely written and verbal updates to supervisors and cross-functional stakeholders regarding production progress, technical challenges, and operational priorities.
• Maintain a safe, clean, and compliant manufacturing environment in accordance with established SOPs, safety requirements, and cGMP standards.
• Complete required training within established timelines and maintain compliance with applicable company policies and regulatory requirements.
• Perform plasmid DNA (pDNA) digestion, in vitro transcription (IVT), purification, and related manufacturing processes using specialized equipment in accordance with approved procedures.
• Execute enzymatic reactions and purification processes, including operation of purification systems, preparation of batch documentation, and implementation of SOPs.
• Perform gram-to-kilogram-scale chemical synthesis, including organic reactions, precipitation, salt exchange, extraction, deprotection, chromatography, fill-finish, and aliquoting of mRNA capping reagents, modified nucleoside triphosphates (NTPs), and other biotechnology raw materials.
• Perform synthetic oligonucleotide manufacturing activities, including chemical reactions, purification, processing, and associated batch documentation.
• Perform other functions and duties as required.

The skills and experience that you will bring

• Bachelor's degree in Chemistry, Biochemistry, Biology, Molecular Biology, or a related scientific discipline, or equivalent combination of education and relevant experience.
• Minimum of 2 years of experience in a biochemistry, biotechnology, or related manufacturing laboratory environment.
• Experience following, reviewing, and executing standard operating procedures (SOPs) and maintaining accurate manufacturing documentation.
• Strong organizational skills, attention to detail, and demonstrated ability to troubleshoot and resolve technical issues.
• Effective written and verbal communication skills, with the ability to collaborate across cross-functional teams.
• Ability to work independently, manage competing priorities, and meet established production timelines.
• Experience working in a current Good Manufacturing Practice (cGMP) environment, including ISO Class 7 or ISO Class 8 cleanrooms.
• Experience drafting, revising, and implementing SOPs, batch records, and other controlled manufacturing documents.
• Hands-on experience with chemical synthesis and purification processes involving mRNA capping reagents, modified nucleoside triphosphates (NTPs), or other biotechnology raw materials at scales ranging from 1 to 500 grams.
• Familiarity with manufacturing equipment operation, troubleshooting, preventive maintenance, and process improvement initiatives.
• Proficiency in Microsoft Office Suite, including Word, Excel, and Outlook.

Pay and benefits

The anticipated hourly rate for this position is $25 - $30 per hour. The offer will depend on multiple factors which may include the successful candidate's skills, experience and other qualifications, as well as the location of the role.

#LI-Onsite

The benefits of being a #MiracleMaker

• You have the potential to change, improve, and save lives around the world.
• You have the opportunity to be a part owner in Maravai through RSU grants and optional employee stock purchase plans.
• We offer comprehensive medical plans and HSA/FSA options.
• Fertility & family planning assistance.
• A variety of additional optional benefits and insurance options, including pet insurance.
• Retirement contributions.
• Holidays & Paid Time Off.

Benefits may vary by region and employment type and do not apply to temporary employees or contractors.