Postdoctoral Associate | Bennett Lab

About the role

Postdoctoral Associate Bennett Lab The Jackson Laboratory Bar Harbor, ME. The Bennett Lab is dedicated to uncovering the fundamental mechanisms that govern the developmental emergence of hematopoietic stem cells (HSCs) and translating these insights toward improved stem cell engineering for regenerative medicine.

The laboratory focuses on understanding HSC specification and maturation in embryonic development by: 1) defining how TGF- /BMP signaling regulate the transition from pre-HSCs to transplantable HSCs, including the role of SMAD7 and related downstream effectors.

2) the identification of novel regulators to this process and defining how rare pre-hematopoietic stem cell intermediates arise from hemogenic endothelium and mature into fully functional, multi-lineage engraftable HSCs. Our long-term goal is to identify the precise molecular signals that enable robust HSC formation and use this knowledge to improve the efficiency of producing of transplantable HSCs for therapeutic purposes.

The Bennett lab uses a multidisciplinary approach integrating mouse genetics, embryo models, transplantation assays, flow cytometry, confocal microscopy, clonal barcoding, and single-cell genomics. The lab offers a highly collaborative environment with opportunities to work across programs at The Jackson Laboratory as well as with external collaborators in the field.

Trainees will be supported in fellowship applications, publications, conference presentations, and career development toward academic or industry paths.

Responsibilities

The successful candidate will be able to plan, develop, execute, and analyze an independent research project within the lab's main focus areas. Potential projects may include mechanistic studies into how TGFb/BMP signaling pathways regulates pre-HSC maturation or mapping transcriptional states of developmental HSC emergence using single-cell and clonal barcoding approaches.

Additional responsibilities include preparing manuscripts, fellowship applications, and conference presentations, as well as mentoring junior lab members and contributing to a collaborative team environment.

Required Qualifications * Ph.D., M.D., or equivalent degree in biological sciences or related discipline * Minimum of one first-author publication from graduate studies or prior postdoctoral work * Strong foundational training in molecular biology, cell biology, developmental biology, or stem cell biology * Excellent verbal and written communication skills * Self-motivated and able to work independently as well as collaboratively Preferred Qualifications Experience or training in any of the following areas: * Hematopoiesis, stem cell biology, developmental biology, or vascular biology * Mouse models, transplantation assays, or in vivo lineage tracing * Flow cytometry, cell sorting, and primary cell culture * Single-cell RNA-seq, ATAC-seq, spatial genomics, or related genomic technologies * Lentiviral systems or clonal barcoding * Computational biology, bioinformatics, or quantitative data analysis How to Apply A complete application must include a cover letter describing past research accomplishments, current research interests, and career aspirations; a current CV; and the names and contact information of three references.

JAX Salary Year 0 - 1: $65,589 Year 1 - 2: $67,318 Year 2 - 3: $69,095 Year 3 - 4: $70,521 Year 4 - 5: $72,877 Year 5 - 6: $75,569 Based on years of experience as Postdoc About JAX: The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California), Japan and China.

Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health. Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease.

It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community.