Treeline Biosciences
Healthcare & Life SciencesDirect Greenhouse career site

Principal Information System Engineer

Pay
$180,250 – $196,751 per year
Location
Watertown, MA · On-site
Job type
Full-time
Level
Executive
Experience
8+ years
Education
Bachelor's degree
Listed
30 days ago

Skills & highlights for this role

  • Microsoft Intune
  • Microsoft Entra ID
  • Okta
  • Multi-Factor Authentication
  • PowerShell

Also useful

  • ManageEngine Endpoint Central
  • ITSM processes

Summary

We are seeking an experienced and customer-focused Principal Information System Engineer to join our IT team. The ideal candidate will have strong experience managing modern workplace technologies and troubleshooting complex technical issues. This role reports to our Director, IT Operations and will work closely with both our in-house engineers and Managed Service Providers (MSPs) supporting Treeliners from every department across multiple countries.

Responsibilities

  • Serve as the primary technical escalation point for the IT organization, including providing hands-on support to end users as needed.
  • Hands-on leadership for complex technical initiatives.
  • Serve as a secondary technical decision-maker for IT Operations, providing recommendations to the Director on tooling, standards, and vendor issues.
  • Administer, support, and optimize cloud-based enterprise technologies, including endpoint, identity, and security management solutions.
  • Manage modern workplace technologies and troubleshoot complex technical issues.
  • Administer and maintain Microsoft 365, Microsoft Intune, and Microsoft Entra ID environments, including Conditional Access Policies and endpoint security configurations.
  • Manage identity and access solutions, including Okta and Multi-Factor Authentication (MFA), to safeguard Treeline systems and data.
  • Develop and maintain PowerShell scripts to automate routine administrative tasks and improve operational efficiency.
  • Partner with in-house engineers and MSPs to support employees across multiple departments and countries.
  • Maintain accurate documentation, ticket updates, and knowledge base articles in accordance with established ITSM processes.
  • Collaborate with local and remote coworkers and vendors to design, implement, and continuously improve IT solutions.

Qualifications

  • Bachelor's degree in Information Technology, Computer Science, or related field, or equivalent work experience.
  • 8-10+ years of experience in systems administration, endpoint management, identity management, or IT operations.
  • A broad range of overall IT experience, including Windows, Mac, Databases, Storage, Security, Networking and public clouds.
  • Strong hands-on experience with the following or similar:
  • Microsoft 365 Administration
  • Microsoft Intune
  • ManageEngine Endpoint Central
  • Microsoft Entra ID, including Conditional Access Policies
  • Okta
  • Endpoint security and device management
  • Multi-Factor Authentication (MFA)
  • PowerShell (Basic to Intermediate)
  • Strong troubleshooting, problem-solving, and analytical skills.
  • A track record of taking ownership in issue resolution. No problem is too big or too small.
  • Organized and detail orientated.
  • Excellent written and verbal communication skills, including clear documentation, ticket updates, and knowledge base contributions.
  • Familiarity with ticketing systems and ITSM processes
  • Experience working collaboratively with coworkers and vendors, both local and remote, while also being effective working independently.
  • You are curious, creative, and innovative and want to continuously improve our processes.
  • Previous experience working in a biotech startup or biopharmaceutical.
  • Related certifications are a plus
  • Ability to explain technical issues clearly to non-technical users
  • Patient, customer-focused mindset with a commitment to service quality
  • Ability to prioritize tasks and manage multiple issues simultaneously

Pay and benefits

This position is classified as exempt. The anticipated annual base salary range for candidates who will work in Watertown is $180,250 to $196,751. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.

Read the original posting

From Treeline Biosciences's careers page, first listed on Rolev.ai on October 10, 2026. Rolev.ai is not the employer.

How Rolev.ai helps with this application

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Common questions

What is the salary for the Principal Information System Engineer role at Treeline Biosciences?

The Principal Information System Engineer posting at Treeline Biosciences states compensation of $180,250 – $196,751 per year. It is listed as a full-time position. Final pay may depend on location, experience, and interview evaluation on Treeline Biosciences's official career site.

Where is the Principal Information System Engineer job at Treeline Biosciences located?

This Principal Information System Engineer position at Treeline Biosciences is located in Watertown, MA (On-site). Always check Treeline Biosciences's application page for specific state eligibility or relocation policies.

What qualifications are required for Principal Information System Engineer at Treeline Biosciences?

For the Principal Information System Engineer role, Treeline Biosciences highlights 8+ years of relevant experience; a bachelor's degree; experience with Microsoft Intune, Microsoft Entra ID, Okta, Multi-Factor Authentication, PowerShell. Rolev.ai can score your existing resume against these requirements and show any skill gaps before you apply.

How do I apply for the Principal Information System Engineer position at Treeline Biosciences?

This listing links directly to Treeline Biosciences's Greenhouse application page. You can apply directly on Treeline Biosciences's site, or use Rolev.ai to check your resume fit, generate a zero-hallucination tailored resume and cover letter for this posting, and autofill the Greenhouse application form in 1 click with the Rolev.ai Chrome extension. You always review the form and press Submit yourself.