Principal Scientist
- Pay
- $143,200 – $265,900 per year
- Location
- South San Francisco, CA · On-site
- Job type
- Full-time
- Level
- Lead / Staff
- Experience
- 3+ years
- Education
- Doctorate
- Listed
- 21 days ago
Skills & highlights for this role
- LC-MS/MS
- LC-HRMS
- sample preparation (precipitation, liquid-liquid, solid-phase extraction)
- bioanalytical quality control
Also useful
- Generative AI tools
- mass spectrometry data processing
The Opportunity
SE7
As a Principal Scientist in Small Molecule Biomarkers (Metabolomics & Lipidomics) within our Drug Metabolism and Pharmacokinetics (DMPK) team, you will play a key role in advancing safe and effective therapeutics for patients. Joining Genentech Research and Early Development (gRED), you will empower drug discovery across the organization by developing high-throughput mass spectrometry workflows and applying modern tools—including Generative AI—to drive biological insights.
Key Responsibilities
- Method Development: Design and apply LC-HRMS and LC-MS/MS methods to acquire high-quality mass spectrometry biomarker data supporting drug discovery and development.
- Experimental Execution: Prepare and execute global and targeted metabolomics and lipidomics protocols across diverse biological specimens, including biofluids, tissues, and cells.
- Data & AI Workflows: Perform mass spectrometry data processing and statistical analysis; build or leverage Generative AI tools and software workflows to scale analysis and reporting.
- Quality & Insight: Oversee rigorous bioanalytical quality control using common industry practices and critical analytical reasoning.
- Cross-Functional Collaboration: Partner with multidisciplinary teams and project stakeholders to translate complex omics data into actionable drug target research.
Who You Are
You are an innovative analytical scientist with a passion for cellular metabolism, mass spectrometry technology, and emerging computational tools. You thrive in collaborative, high-impact environments and want to translate cutting-edge omics data into life-changing medicines.
Qualifications & Experience
- Education & Industry Experience: PhD in biological, chemical, pharmaceutical sciences, or a related field, accompanied by 3–5 years of direct experience in the biotechnology or pharmaceutical industry.
- Bioanalytical Expertise: Proven experience designing and executing assays for endogenous small molecule metabolites or lipids, including sample preparation techniques like precipitation, liquid-liquid, or solid-phase extraction.
- Technical Mastery: Practical experience operating and troubleshooting modern LC-MS platforms (e.g., UHPLC, triple quadrupole, high-resolution mass spectrometers) and using analytical data processing software.
- Metabolic & Computational Insight: Solid foundation in cellular metabolism, coupled with hands-on experience or strong aptitude using Generative AI tools for coding and biological insight generation.
- Collaboration & Communication: Excellent communication skills with a proven track record of working effectively in multidisciplinary project teams.
Relocation benefits are available for this posting.
Pay and benefits
The expected salary range for this position based on the primary location of California is $143,200 - $265,900. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Equal opportunity and legal notices
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
From Roche's careers page, first listed on Rolev.ai on October 20, 2026. Rolev.ai is not the employer.
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Common questions
What is the salary for the Principal Scientist role at Roche?
The Principal Scientist posting at Roche states compensation of $143,200 – $265,900 per year. It is listed as a full-time position. Final pay may depend on location, experience, and interview evaluation on Roche's official career site.
Where is the Principal Scientist job at Roche located?
This Principal Scientist position at Roche is located in South San Francisco, CA (On-site). Always check Roche's application page for specific state eligibility or relocation policies.
What qualifications are required for Principal Scientist at Roche?
For the Principal Scientist role, Roche highlights 3+ years of relevant experience; a doctorate; experience with LC-MS/MS, LC-HRMS, sample preparation (precipitation, liquid-liquid, solid-phase extraction), bioanalytical quality control. Rolev.ai can score your existing resume against these requirements and show any skill gaps before you apply.
How do I apply for the Principal Scientist position at Roche?
This listing links directly to Roche's Workday application page. You can apply directly on Roche's site, or use Rolev.ai to check your resume fit, generate a zero-hallucination tailored resume and cover letter for this posting, and autofill the Workday application form in 1 click with the Rolev.ai Chrome extension. You always review the form and press Submit yourself.