Principal Scientist, Process Chemistry

Position Description

Calico is seeking an experienced Process Chemist to join our laboratory-based chemical development team. The ideal candidate brings extensive hands-on experience in process research, route scouting, and scale-up of organic molecules. In this role, you will design, optimize, and execute synthetic processes that enable efficient, safe, and scalable manufacturing of small-molecule intermediates and APIs. This is a lab-focused position requiring strong experimental skills, deep organic chemistry knowledge, and the ability to translate laboratory findings into robust processes.

Key Responsibilities

• Develop, optimize, and troubleshoot synthetic routes for intermediates and drug substance candidates
• Perform laboratory experiments to improve yields, selectivity, throughput, and impurity control
• Conduct detailed reaction analysis using, HPLC, GC, LC-MS, and other analytical techniques
• Perform impurity identification and synthesis
• Identify and mitigate process risks related to safety, scalability, and robustness
• Collaborate with cross-functional partners including analytical chemistry, formulations, and quality assurance
• Prepare clear, data-driven reports and present experimental results to project teams
• Support technology transfer to contract manufacturing organizations, including review of master batch records and process descriptions
• Maintain accurate lab documentation and adhere to all safety and compliance standards

Position Requirements

• PhD in Organic Chemistry or related field with 8+ years of relevant industrial experience in process chemistry
• Strong expertise in synthetic organic chemistry and reaction mechanism fundamentals
• Demonstrated success in developing scalable synthetic processes
• Proficiency with standard analytical instruments and data interpretation
• Excellent problem-solving, organization, and communication skills
• Ability to work independently while contributing effectively to a team environment
• Familiarity with cGMP and ICH guidelines
• Strong attention to detail and a commitment to high-quality experimentation
• Ability to manage multiple projects and shifting priorities
• A proactive, collaborative mindset with enthusiasm for process improvement
• Must be willing to work onsite 5 days a week

Pay and benefits

The estimated base salary range for this role is $197,000 - $230,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.