Process Development Engineer
- Location
- Redwood City, CA
- Listed
- Today
What You'll Do
- Design, develop, and implement methods to scale oligonucleotide synthesis and purification
- Synthesize, purify and analyze oligonucleotides to specifications, using proprietary and commercial instrumentation
- Analyze data from assays such as UV, chromatograms and mass spectrometry for optimizing experimental conditions and determining root causes of failures
- Work alongside a cross-functional group of Chemists, Engineers, and Scientists to execute developmental processes and collaborate on designed experiments.
- Conduct experimentation using automated instrumentation and liquid handling equipment
- Write development protocols and reports and regularly present findings to interdepartmental stakeholders
- Conduct IQ/OQ/PQ for new instrumentation acquired for development projects
- Practice continuous improvement by contributing ideas and suggestions to new and existing processes
- Generate and maintain records or documents in a detailed and consistent manner
- Assist with Quality data management, including writing new or updating Standard Operating Procedures, Batch Records, and Change Control documents
- Work with vendors to acquire reagents, consumables, or instrumentation as needed for development efforts
- Train others on new or updated processes and procedures
About You
- BS in Chemistry, Chemical Engineering, Bio-engineering or a similar field
- 2-5 years of industry experience within a research/manufacturing/production environment, preferably in a small company/start-up setting
- Direct experience in the synthesis and analysis of oligonucleotide products
- Experience in data analysis with languages such as Python, SQL.
- Understanding of aseptic handling techniques, including liquid handling, pipetting, reagent preparation, and consumables.
- Experience using larger scale instrumentation such as HPLCs, oligonucleotide or peptide synthesizers, tangential flow filtration, and/or liquid handlers.
- Strong desire to work in a fast-paced, collaborative start-up environment
- Demonstrates strong interpersonal and communication skills (both written and oral)
- Demonstrates ability to work independently and as part of a team to curate and execute development projects.
Nice to Have
- Deep knowledge of oligonucleotide chemistry or reagent manufacturing, specifically using fluorophores, quenchers, or other oligonucleotide modifiers
- Familiar with qPCR
- Familiar with fluorescence assays and how to create functional tests for newly developed products
- Familiar with biotechnical instrumentation in aspects such as coding new methods, data analysis pipeline, servicing, etc
Company Perks & Benefits
- Medical, dental, and vision benefits
- 401k Program
- Catered meals on Tuesday and Thursday
- Paid parental leave
- Flexible paid time off
- Education Reimbursement Program
About Synthego
Synthego is enabling genome engineering at scale with a blend of scientific instrumentation, industrial automation, and data science. Our team of scientists and engineers are putting multidisciplinary fields together to solve problems that no one field can tackle alone.
We are searching for a motivated and enthusiastic individual to join our Chemistry Development team to improve our oligonucleotide manufacturing process and to directly contribute to launching new oligonucleotide products. As a Process Development Engineer at Synthego, you will have direct responsibility for the development of new techniques for synthesis and purification of RNA and DNA from nanomole to millimole scales.
Primary goals include scaling manufacturing processes, improving cost and margin, improving quality of oligonucleotide products, and reducing production times. This role will include developing in both a research and clinical environment, as well as transferring technology into the manufacturing lines.
With a focus on the successful introduction and adoption of new technologies in operations, this role will collaborate closely with the hardware, software, operations, quality, and product teams.
Our Mission
Synthego is a pioneering force in the biotechnology industry, dedicated to advancing the frontiers of CRISPR cell and gene therapies through cutting-edge CRISPR technology and expertise. Our mission is to provide unparalleled access to best-in-class CRISPR solutions at scale, empowering agility in life science research and development from discovery through clinical trials. From streamlined approaches to licensing through full technical and regulatory support from our industry-leading experts, Synthego is enabling greater access to CRISPR technology driving to improved outcomes in patient therapeutic treatments.
From Synthego's careers page, first listed on Rolev.ai on November 12, 2026. Rolev.ai is not the employer.
How Rolev.ai helps with this application
Rolev.ai is a job search and application tool for US job seekers. For this Process Development Engineer role at Synthego, it shows how your resume fits, tailors your resume to the posting, and prepares the application for you to review.
See how you fit
Openings from employer career sites are ranked against your whole resume—and searchable inside Claude, ChatGPT, and Cursor via Rolev.ai MCP.
Tailor without inventing
Every change to your resume is checked against your original. New experience goes in only with your yes—zero fabricated claims.
Draft the full kit
Tailored and Full Match resumes, role-specific cover letters, and answers to employer screening questions are prepared in seconds.
1-Click Extension Autofill
The Chrome extension fills the employer's Greenhouse, Workday, Lever, or Ashby form in 1 click. You review it and press Submit.
Similar roles
- Process Development Engineering ManagerPOET · Scotland, SD
- Process Development Associate Scientist, Drug Product Visual Inspection SciencesAmgen · Thousand Oaks, CA
- Process Development Engineer IIBlue Origin · Greater Seattle Area
- Process Development EngineerFlir · Goleta, CA
- Process Development EngineerXylem · Tewksbury, MA · $100k – $125k/yr
- Process Development EngineerMarmon · Harlingen, TX
Common questions
Where is the Process Development Engineer job at Synthego located?
This Process Development Engineer position at Synthego is located in Redwood City, CA. Always check Synthego's application page for specific state eligibility or relocation policies.
How do I apply for the Process Development Engineer position at Synthego?
This listing links directly to Synthego's Lever application page. You can apply directly on Synthego's site, or use Rolev.ai to check your resume fit, generate a zero-hallucination tailored resume and cover letter for this posting, and autofill the Lever application form in 1 click with the Rolev.ai Chrome extension. You always review the form and press Submit yourself.