Biosphere
Direct Greenhouse career site

Process Engineer

Location
Oakland, CA · On-site
Job type
Full-time
Level
Senior
Experience
1+ year
Education
Bachelor's degree
Listed
14 days ago

Skills & highlights for this role

  • Mass and energy balances
  • Fluid flow
  • Heat transfer
  • Pump and line sizing
  • P&ID creation and review
  • Process flow diagrams (PFDs)
  • Equipment sizing and specification
  • Piping and instrumentation
  • Pilot plant operations
  • Technical documentation
  • Hands-on mechanical assembly

Also useful

  • Fermentation
  • Bioprocess experience
  • Sterile design
  • SIP/CIP
  • Aseptic operation
  • ASME BPE
  • EHEDG
  • FEL/FEED packages

About the Role

We are looking for a Process Engineer to support the design of our 20 m³ demonstration facility and to build and run pilot-scale UV bioreactors. The work is split between design and hands-on building. You will work on mass and energy balances, PFDs, P&IDs and equipment specifications for the demo plant. On the hands-on side you will pipe, instrument, commission and operate pilot reactors. This role is in person at our Oakland, CA facility and reports to the Principal Process Engineer. Title and level (Engineer I, II or III) will be set based on experience.

Responsibilities

  • Contribute to process design deliverables for the demonstration facility: design basis, mass and energy balances, PFDs, P&IDs, equipment lists and specifications, and process control narratives.
  • Size and specify process equipment and utilities (vessels, pumps, heat exchangers, filtration, piping, valves, instruments) and support vendor selection and quote review.
  • Design, build and commission pilot-scale UV bioreactors (roughly 100 L to 2 m³), including piping, instrumentation and basic controls integration.
  • Operate pilot equipment alongside R&D: run fermentation and sterilization tests, collect data, and turn results into design changes.
  • Support design reviews, HAZOPs, FAT/SAT and commissioning for demo plant equipment.
  • Work with our engineering partners, vendors and fabricators, and review their deliverables.
  • Help maintain up-to-date documentation, including but not limited to drawings, specifications, procedures, and test batch reports.
  • Continue to build and maintain a safety-first culture in the lab, shop, pilot spaces, and plant.

Qualifications

  • BS in Chemical Engineering or a related field (bioengineering, mechanical engineering).
  • 1 to 6 years of experience in process engineering, process development, or pilot plant / manufacturing operations. New graduates with strong co-op or internship experience will be considered for Engineer I.
  • Solid chemical engineering fundamentals: mass and energy balances, fluid flow, heat transfer, pump and line sizing.
  • Can read and produce P&IDs.
  • Hands-on experience: you're comfortable using wrenches, assembling sanitary tubing, wired instruments, or building skids and are interested in continuing to build on that experience
  • Clear writer, strong communicator, organized, and able to run small projects with minimal oversight.
  • Able to lift 50 lb, stand for extended periods, and wear PPE.
  • Due to the requirements of our federal contracts, candidates must be a U.S. citizen or permanent resident.

Preferred Skills

  • Fermentation or bioprocess experience, including sterile design, SIP/CIP, and aseptic operation.
  • Familiarity with hygienic design standards (ASME BPE, EHEDG).
  • Experience in food/beverage, pharma, specialty chemicals, or an industrial biotech pilot plant.
  • Experience producing or reviewing FEL/FEED packages and/or working with an external engineering firms.
  • CAD for process documentation (AutoCAD Plant 3D, SolidWorks or similar).
  • Exposure to PLCs, SCADA and instrumentation.
  • Comfortable working in an early-stage company, adapting to uncertainty and evolving priorities as the business grows.

Benefits

  • Competitive compensation through a mix of salary and equity.
  • Unlimited paid vacation and sick/leave days + public holidays.
  • Comprehensive health insurance for employees and their dependents, including dental and vision.
  • Paid family leave.
  • Membership at Pacific Pipe Climbing gym next door.

This Role Might Be For You If You

  • Want to work on both the design and the build of new process equipment.
  • Are excited about biomanufacturing and want to make it cheaper and more accessible.
  • Thrive in small teams where your work directly shapes the company's trajectory.
Read the original posting

From Biosphere's careers page, first listed on Rolev.ai on October 26, 2026. Rolev.ai is not the employer.

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Common questions

Where is the Process Engineer job at Biosphere located?

This Process Engineer position at Biosphere is located in Oakland, CA (On-site). Always check Biosphere's application page for specific state eligibility or relocation policies.

What qualifications are required for Process Engineer at Biosphere?

For the Process Engineer role, Biosphere highlights 1+ year of relevant experience; a bachelor's degree; experience with Mass and energy balances, Fluid flow, Heat transfer, Pump and line sizing, P&ID creation and review, Process flow diagrams (PFDs). Rolev.ai can score your existing resume against these requirements and show any skill gaps before you apply.

How do I apply for the Process Engineer position at Biosphere?

This listing links directly to Biosphere's Greenhouse application page. You can apply directly on Biosphere's site, or use Rolev.ai to check your resume fit, generate a zero-hallucination tailored resume and cover letter for this posting, and autofill the Greenhouse application form in 1 click with the Rolev.ai Chrome extension. You always review the form and press Submit yourself.