Project Toxicologist
- Pay
- $104,900 – $194,900 per year
- Location
- Philadelphia, PA · On-site
- Job type
- Full-time
- Level
- Senior
- Experience
- 2+ years
- Education
- Doctorate
- Listed
- 17 days ago
Skills & highlights for this role
- Toxicology or pharmacology expertise
- Design, execution, and interpretation of GLP and non-GLP nonclinical safety studies
- Understanding of drug development processes
- Scientific communication
- Cross-functional collaboration
Also useful
- Genetic medicines experience
- Viral vector (AAV) experience
- Gene editing platform experience
- RNA/oligonucleotide modality experience
- Ocular or CNS-targeted therapeutic experience
- Authoring nonclinical regulatory modules for IND/CTA dossiers
- Health authority interaction experience
- Managing multiple complex safety programs
About the role
The Opportunity As a Regulatory/Project Toxicologist within our Department of Pharmacology and Toxicology, you will spearhead the nonclinical safety strategy for Roche innovative genetic medicine portfolio. In this role, you will champion the safety evaluation of cutting-edge gene therapies-focusing on ocular- and CNS-directed programs-from early discovery through late-stage clinical development.
You will collaborate with world-class multidisciplinary scientists, driving decisions that safely accelerate groundbreaking medicines to patients. Serve as the nonclinical safety lead and primary toxicology representative on cross-functional drug development project teams across discovery, pre-clinical, and clinical stages.
Formulate, design, and direct integrated nonclinical safety and toxicology strategies (GLP and non-GLP) to support program progression and key regulatory milestones. Lead proactive safety risk identification and design investigative mechanistic studies to evaluate and mitigate treatment-related toxicities.
Partner cross-functionally with Research Leads, Clinical, Regulatory, CMC, and external CROs to coordinate study execution, review protocols, and interpret complex safety data. Author and review comprehensive nonclinical safety documentation, high-level regulatory filings (e.g., INDs, CTAs, PIPs, BLAs, GMO applications), and clinical documents (Investigator Brochures, ICFs).
Communicate scientific findings and safety risk assessments clearly to internal governance committees and represent the organization in meetings with global health authorities.
Pay and benefits
You hold a Ph.D. in Toxicology, Pharmacology, or a closely related scientific discipline. You bring a minimum of 2-3 years of relevant toxicology experience within the biopharmaceutical, biotechnology, or contract research (CRO) industry. You possess demonstrated experience in designing, executing, and interpreting robust nonclinical safety studies (GLP and non-GLP) that drive scientific and portfolio decisions.
You demonstrate a working understanding of drug development processes and the role of nonclinical safety in guiding regulatory and early clinical strategies. You are an exceptional communicator and collaborator, recognized for critical data interpretation, complex scientific problem-solving, and cross-functional leadership.
Preferred Direct experience with genetic medicines, viral vectors (particularly AAVs), gene editing platforms, or novel RNA/oligonucleotide modalities. Prior experience with ocular- or central nervous system (CNS)-targeted drug delivery or therapeutic development. Demonstrated track record of authoring nonclinical regulatory modules for global health authority dossiers (IND/CTA) and participating in health authority interactions.
Proven ability to manage multiple complex safety programs simultaneously while driving collaborative relationships with CRO partners and academic collaborators. The expected salary range for this position based on the primary location of Philadelphia is $104,900 to $194,900 Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.
A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Equal opportunity and legal notices
Relocation benefits are available for this job posting. #LI-PL1 Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence.
The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
From Roche's careers page, first listed on Rolev.ai on October 24, 2026. Rolev.ai is not the employer.
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Common questions
What is the salary for the Project Toxicologist role at Roche?
The Project Toxicologist posting at Roche states compensation of $104,900 – $194,900 per year. It is listed as a full-time position. Final pay may depend on location, experience, and interview evaluation on Roche's official career site.
Where is the Project Toxicologist job at Roche located?
This Project Toxicologist position at Roche is located in Philadelphia, PA (On-site). Always check Roche's application page for specific state eligibility or relocation policies.
What qualifications are required for Project Toxicologist at Roche?
For the Project Toxicologist role, Roche highlights 2+ years of relevant experience; a doctorate; experience with Toxicology or pharmacology expertise, Design, execution, and interpretation of GLP and non-GLP nonclinical safety studies, Understanding of drug development processes, Scientific communication, Cross-functional collaboration. Rolev.ai can score your existing resume against these requirements and show any skill gaps before you apply.
How do I apply for the Project Toxicologist position at Roche?
This listing links directly to Roche's Workday application page. You can apply directly on Roche's site, or use Rolev.ai to check your resume fit, generate a zero-hallucination tailored resume and cover letter for this posting, and autofill the Workday application form in 1 click with the Rolev.ai Chrome extension. You always review the form and press Submit yourself.