Research Opportunities - Gastroenterology (Hepatology)

About the role

• Location
• SAINT LOUIS, MO 63110
• Scheduled Hours
• 40

Position Summary

The Schwartz Laboratory in the Division of Gastroenterology, Department of Medicine, at Washington University School of Medicine in St. Louis is seeking motivated and creative technicians, scientists and postdocs to join our interdisciplinary research program investigating: the biology of hepatitis B virus (HBV) and the mechanisms that allow the virus to establish and maintain chronic infection; how SARS-CoV-2 and other respiratory pathogens interact with human tissue; working at the forefront of human liver tissue engineering and regenerative medicine; the fundamental cell biology of the liver; how hepatocytes, cholangiocytes, stromal and endothelial cells establish and maintain liver architecture, respond to injury, and regenerate; and how metabolic dysfunction, cellular communication, and genetic alterations contributing to liver disease and cancer.

Our long-term goals are: to understand the complex interactions between HBV and its host that drive viral persistence and to use these insights to identify new strategies toward a functional cure for chronic hepatitis B, which remains a major global health challenge and an important cause of liver-related morbidity and mortality; to establish a multi-organ organoid and stem cell-derived platform that contributes to our understanding of viral pathogenesis and host immune responses; to develop GMP-grade, hypoimmunogenic bioartificial liver for transplantation; to determine how the different liver cells respond to injury and their impacts on regeneration and fibrosis; and to uncover fundamental mechanisms of disease and identifying new opportunities for therapeutic intervention.

We are seeking individuals with prior experience in molecular biology, biochemistry, genetics and/or cell biology.

Projects and requirements will vary depending on candidate background and experience.

Working Conditions

This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.

Salary Range

Base pay is commensurate with experience.

The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.

Required Qualifications

Education

Bachelor's degree or combination of education and/or experience may substitute for minimum education.

Certifications /Professional Licenses

• No specific certification/professional license is required for this position.
• Work Experience: No specific work experience is required for this position.

Skills: Not Applicable

Driver's License: A driver's license is not required for this position.

Preferred Qualifications

• Experience with mouse handling, husbandry, and/or survival surgery.
• Experience in liver, gastrointestinal, or developmental biology research.
• Experience with primary hepatocyte or other primary cell culture.
• Experience in histology, immunofluorescence, or imaging-based analysis.
• Experience in bioengineering.
• Experience in molecular virology.
• Demonstrated analytical, reasoning and problem-solving skills.
• Ability to analyze and interpret statistical data and to communicate data in a clear, concise manner.
• Adept at using Microsoft Office Suite and the ability to use software packages to analyze data.

Preferred Qualifications

Education: No additional education unless stated elsewhere in the job posting.

Certifications/Professional Licenses

No additional certification/professional licenses unless stated elsewhere in the job posting.

Work Experience

No additional work experience unless stated elsewhere in the job posting.

Skills

Communication, Laboratory Research, Organizing, Recordkeeping, Working Independently:

• Grade
• 00
• Questions

For frequently asked questions about the application process, please refer to our External Applicant FAQ.

Accommodation

If you are unable to use our online application system and would like an accommodation, please email or call the dedicated accommodation inquiry number at and leave a voicemail with the nature of your request.

Pre-Employment Screening

All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.

Benefits Statement

Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours.