Research Scientist I / II - High Throughput Chemistry

Job Summary

We are seeking a highly skilled and motivated Research Scientist to join our Discovery Chemistry team at Iambic Therapeutics in San Diego, CA. In this role, the ideal candidate will exploit their strong background in organic synthesis, catalysis, and reaction development to design, optimize, and execute high-throughput experiments to drive compound library campaigns.

The successful candidate will deliver impact cross-functionally with chemistry, biology, compound management, AI/ML, and software teams across the discovery pipeline, leveraging Iambic's HTE platform to accelerate and strengthen our programs. This position will be based in our San Diego Headquarters.

Key Responsibilities

• Design and execute parallel synthetic methods to generate large, high-quality compound libraries.
• Identify, develop, and optimize novel synthetic methodologies with a focus on automation compatibility and HTE scalability.
• Apply newly developed synthetic routes from traditional bench-scale chemistry to robust, high-throughput, and automated processes.
• Oversee the operation, maintenance, and continuous advancement of our chemistry toolkit and automated synthesis equipment.
• Analyze research outcomes and library compound data and clearly communicate results and findings to cross-functional project teams.
• Ensure all laboratory work is conducted in accordance with established safety protocols and best laboratory and ELN data recording practices.
• Function as a core member of an interdisciplinary scientific team (chemistry, biology, software, and automation).
• Proactively identify bottlenecks, troubleshoot automated processes, and develop solutions to ensure business continuity.

Qualifications

Required

• Ph.D. in Organic Chemistry with 0-5 years of industry experience or MS in Organic Chemistry with a minimum of 8 years of industry experience.
• Strong command of modern organic synthetic methods.
• Direct hands-on experience with High Throughput Chemistry and/or Parallel Synthesis.
• Experience with laboratory automation, liquid handling robotics, and automated analytical and purification systems.
• Ability to thrive in a fast-paced, highly collaborative, and dynamic research environment.
• Excellent written and verbal communication skills; must be able to articulate complex scientific concepts, technical challenges, and results clearly and concisely to diverse audiences.
• Proven ability to thrive in a fast-paced, high-volume environment where priorities and synthetic targets may shift rapidly based on biological data.

Strongly Preferred

• Experience with Direct-to-Biology (D2B) strategies for drug discovery.
• Familiarity with the principles of medicinal chemistry.
• Prior experience mentoring interns or junior colleagues.

Mission & Core Values

Our mission is to deliver better medicines through innovations in AI-based discovery technologies. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.

Pay and Benefits

We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.