Scientist, Genome Sciences & Engineering
- Pay
- $125,000 – $140,000 per year
- Location
- Cambridge, MA · On-site
- Job type
- Full-time
- Level
- Senior
- Experience
- 5+ years
- Education
- Master's degree
- Listed
- 18 days ago
Skills & highlights for this role
- cell biology or molecular biology expertise
- LNP delivery experience
- primary cell culture (T-cells, hepatocytes) and/or cancer cell line culture
- gene editing technology knowledge (CRISPR nucleases, recombinases, base editors, or transcriptional effectors)
- flow cytometry
- nucleic acid QC (TapeStation, Qubit, NanoDrop, qPCR)
- quantitative data analysis
- scientific written and verbal communication
Also useful
- laboratory automation platforms
- ddPCR
- KromaTiD
- optical genome mapping
- high-throughput screening
- translational and preclinical development experience
About the Role
Stylus Medicine is seeking a Scientist to join our Genome Sciences & Engineering team to drive innovation in next-generation gene editing therapies. In this role, the Scientist will drive the in vitro functional assessment of the company's lead genome editors to support the advancement of the company's lead programs through translational and preclinical development. This individual will play a key role in discovery and engineering efforts, advancing LSR-based genome editing platforms and collaborating across diverse R&D teams.
Key Responsibilities & Accountabilities
- Design and execute in vitro functional assays that support candidate selection and preclinical development of lead genome editors,advancing platform and program objectives
- Develop and optimize molecular (ddPCR, qPCR) and cytogenetic (KromaTiD, optical genome mapping) assays to measure genome editor activity, specificity, transgene copy number, TCR repertoire, and biodistribution
- Support genome editor engineering campaigns by running high-throughput screens in relevant cell lines, including primary human T-cells, and delivering timely, decision-quality data to guide candidate selection
- Troubleshoot experiments, analyze data, and translate results into actionable scientific insights
- Maintain detailed laboratory notebooks and clearly communicate data and findings to the broader scientific team
- Partner across R&D to advance optimized candidates into translational and preclinical development
Qualifications & Skills
- PhD in Cell Biology, Molecular Biology, or a related field; or MS with 5+ years or BS with 7+ years of relevant experience
- Hands-on experience with LNP delivery and expertise culturing primary cells (including, but not limited to T-cells and hepatocytes) and/or cancer cell lines
- Working knowledge of gene editing technologies (CRISPR nucleases, recombinases, base editors, or transcriptional effectors)
- Experience with flow cytometry and laboratory automation platforms for cell-based screening workflows
- Proficiency in nucleic acid QC methods, including TapeStation, Qubit, NanoDrop, and qPCR
- Track record of independently generating reproducible data and performing rigorous quantitative analysis
- Strong written and verbal communication skills, with the ability to present complex technical information to both specialist and non-specialist audiences
- Exceptional organizational skills, comfortable managing complex datasets and overlapping projects
- Strategic thinker who plans and prioritizes for scientific impact
- Clear, approachable communicator who makes complex concepts accessible across disciplines
- Collaborative mindset with a team-first attitude
- Decisive problem-solver who thrives amid scientific uncertainty
Pay and benefits
Pay Range: $125,000 - $140,000
About Stylus Medicine
Stylus Medicine is developing transformative in vivo genetic medicines to unlock cures. Stylus combines engineered recombinases with non-viral delivery to specifically encode therapeutics. The company's approach is versatile and modular, with potential therapeutic application across oncology, autoimmune, genetic diseases, and beyond.
From Stylus Medicine's careers page, first listed on Rolev.ai on October 22, 2026. Rolev.ai is not the employer.
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Common questions
What is the salary for the Scientist, Genome Sciences & Engineering role at Stylus Medicine?
The Scientist, Genome Sciences & Engineering posting at Stylus Medicine states compensation of $125,000 – $140,000 per year. It is listed as a full-time position. Final pay may depend on location, experience, and interview evaluation on Stylus Medicine's official career site.
Where is the Scientist, Genome Sciences & Engineering job at Stylus Medicine located?
This Scientist, Genome Sciences & Engineering position at Stylus Medicine is located in Cambridge, MA (On-site). Always check Stylus Medicine's application page for specific state eligibility or relocation policies.
What qualifications are required for Scientist, Genome Sciences & Engineering at Stylus Medicine?
For the Scientist, Genome Sciences & Engineering role, Stylus Medicine highlights 5+ years of relevant experience; a master's degree; experience with cell biology or molecular biology expertise, LNP delivery experience, primary cell culture (T-cells, hepatocytes) and/or cancer cell line culture, gene editing technology knowledge (CRISPR nucleases, recombinases, base editors, or transcriptional effectors), flow cytometry, nucleic acid QC (TapeStation, Qubit, NanoDrop, qPCR). Rolev.ai can score your existing resume against these requirements and show any skill gaps before you apply.
How do I apply for the Scientist, Genome Sciences & Engineering position at Stylus Medicine?
This listing links directly to Stylus Medicine's Greenhouse application page. You can apply directly on Stylus Medicine's site, or use Rolev.ai to check your resume fit, generate a zero-hallucination tailored resume and cover letter for this posting, and autofill the Greenhouse application form in 1 click with the Rolev.ai Chrome extension. You always review the form and press Submit yourself.