Scientist I, Biochemistry & Lead Discovery
- Location
- Cambridge, MA USA
- Listed
- 6 days ago
The Role
FL111 is seeking an independent and motivated lab scientist with deep understanding of biochemical and biophysical assay design to join the Biochemistry team. This role will lead assay development, target engagement studies, and binding characterization for small molecules, heterobifunctionals, and related modalities, working closely with chemistry and biology to inform hit-to-lead optimization and mechanism-of-action questions. This role also contributes to team leadership, cross-functional collaborations, and broader scientific discussions that support organizational growth.
Key Responsibilities
- Lead and execute biochemical assay development to monitor protein/ligand and protein/protein interactions
- Apply readout technologies such as FP, FRET, NanoBRET, or NanoBiT across active programs
- Drive protein purification and QC processes to support ongoing discovery efforts
- Set up and run high-throughput assays, troubleshooting independently to keep programs moving
- Partner with contract research organizations as needed to extend internal capacity
- Collaborate cross-functionally and contribute scientific input across multiple concurrent projects
Professional Experience & Qualifications
- MS or PhD in Biochemistry, Chemical Biology, Enzymology, or a related field
- MS and at least 8 years of relevant academic or industry experience
- PhD and 0-2 years of relevant academic or industry experience
- Deep understanding of protein chemistry and biophysics, with hands-on experience working with small-molecule compounds
- Demonstrated ability to develop and troubleshoot biochemical assays independently
- Excellent communication skills and the ability to work cross-functionally
- A high degree of scientific independence, motivation, and solutions-oriented thinking
- Comfort operating in a fast-paced environment with shifting priorities
- Experience working with CROs is a plus
Location: Cambridge, MA
Company Description
Flagship Labs 111 Inc. (FL111) is a privately held, early-stage biotechnology company pioneering a novel platform harnessing innovations in chemistry, computation, and data science to create new therapeutic modalities beyond traditional small molecules. FL111 is backed by Flagship Pioneering, bringing the courage, vision, and resources to guide FL111 from platform validation to patient impact. We are seeking collaborative, creative and relentless problem solvers that share our passion for impact to join us!
About Flagship Pioneering
Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value.
Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company's annual list of the World's Most Innovative Companies.
At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
#LI-TL1
Equal opportunity and legal notices
When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations.
Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information.
If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact.
The salary range for this role is $100,000 - $126,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. FL111 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL111's good faith estimate as of the date of publication and may be modified in the future.
Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
From Flagship Pioneering's careers page, first listed on Rolev.ai on November 3, 2026. Rolev.ai is not the employer.
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Common questions
Where is the Scientist I, Biochemistry & Lead Discovery job at Flagship Pioneering located?
This Scientist I, Biochemistry & Lead Discovery position at Flagship Pioneering is located in Cambridge, MA USA. Always check Flagship Pioneering's application page for specific state eligibility or relocation policies.
How do I apply for the Scientist I, Biochemistry & Lead Discovery position at Flagship Pioneering?
This listing links directly to Flagship Pioneering's Greenhouse application page. You can apply directly on Flagship Pioneering's site, or use Rolev.ai to check your resume fit, generate a zero-hallucination tailored resume and cover letter for this posting, and autofill the Greenhouse application form in 1 click with the Rolev.ai Chrome extension. You always review the form and press Submit yourself.