Scientist II, Bioinformatics (Applications Lab)

Opportunity

PacBio is advancing highly accurate long-read sequencing to enable new discoveries and applications in genomics research and genetic testing. We are seeking a Scientist II, Bioinformatics to join our Applications Lab and support production and proof-of-concept sequencing projects. This role will focus on developing and maintaining computational infrastructure, automating data processing workflows, and delivering high-quality bioinformatics analyses for internal and customer projects.

About the Role

As Scientist II, Bioinformatics, you will be a member of PacBio's Applications Lab, an internal customer and services laboratory that supports product development, customer evaluations, and commercial opportunities.

You will be responsible for bioinformatics analyses for internal and customer projects, collaborating with laboratory scientists, Product Management, Marketing, and Sales teams to deliver results that demonstrate the capabilities and value of PacBio technology.

You will also maintain the computational tools and infrastructure needed for laboratory operations, collaborating with laboratory scientists and Information Technology. This includes sample and project tracking, data organization, and automated analysis workflows.

This is a hands-on role requiring strong programming skills, scientific expertise, and the ability to independently troubleshoot complex technical problems.

Responsibilities

• Sequencing lab project support: Collaborate with laboratory scientists to support sequencing projects, ensuring reliable data processing, analysis execution, and timely delivery of results.
• Bioinformatics analysis: Analyze PacBio sequencing data for internal projects, customer evaluations, and proof-of-concept studies. Deliver accurate results, visualizations, and summaries to scientific and commercial stakeholders.
• Laboratory computational infrastructure maintenance: Maintain tools and infrastructure supporting laboratory operations, including sample and project tracking, and data organization.
• Pipeline development and automation: Develop, maintain, and troubleshoot bioinformatics pipelines and automated workflows using Python, Linux, and high-performance computing (HPC) environments. Reduce manual intervention and improve processing reliability.
• Scientific collaboration: Evaluate emerging bioinformatics methods and sequencing applications along with academic and commercial collaborators.

Qualifications

Required

• PhD and a minimum of 0-2 years related experience; may include post-doctoral experience. Alternatively, Masters with a minimum of 3-5 years of relevant experience or B.S. with a minimum of 5-7 years of related experience.
• A degree in Bioinformatics, Biology, Computational Biology, Computer Science, Life Sciences, or a related field.
• Proficiency in Python programming, including data processing.
• Strong working knowledge of Linux, including command-line tools, shell scripting, and file system organization.
• Experience with high-performance computing (HPC) environments, including job schedulers, computational resource allocation, and pipeline execution.
• Familiarity with scientific development practices include testing, version tool, code review, workflow management frameworks (e.g. WDL, NextFlow), reproducible computational environments (containers), and code documentation.
• Experience with next-generation sequencing data analysis and bioinformatics pipelines.
• Strong analytical, troubleshooting, and organizational skills, with the ability to independently solve technical problems and manage multiple priorities.
• Excellent written and verbal communication skills, including the ability to document workflows and explain complex technical concepts to diverse audiences.

Preferred

• Experience working in a sequencing facility, genomics core laboratory, or commercial sequencing service provider.
• Experience with laboratory operations, including sample tracking, metadata management, and project coordination.
• Experience analyzing PacBio HiFi or other long-read sequencing data.
• Experience with cloud-based data storage and analysis, particularly AWS.
• Experience with SQL and relational databases for managing and querying scientific data.
• Familiarity with AI agentic software development tools like Claude Code or Codex.
• Experience in a customer-facing role.
• Experience communicating scientific results in conference presentations or peer-reviewed publications.

Additional information

Candidates must have current authorization to work in the United States without the need for present or future sponsorship.

Non-Field Based Employees are required to be onsite Monday-Thursday (Friday work from home). Depending on the role, some employees may be required to be 100% onsite.

You may be required from time to time to visit and work at PacBio locations and for such times as the Company considers necessary for the proper performance of your duties.

#LI-Onsite

Salary Range

$112,000.00 - $168,000.00

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