Scientist, mRNA Downstream Purification
- Pay
- $120,000 – $155,000 per year
- Location
- South San Francisco, CA · On-site
- Job type
- Full-time
- Level
- Mid-level
- Education
- Doctorate
- Listed
- 20 days ago
Skills & highlights for this role
- tangential flow filtration
- ÄKTA chromatography
- process development
Also useful
- DoE
- plasmid DNA purification
- cGMP
Stated benefits & perks
- Health
- Dental
- Vision
- 401k match
- Paid parental leave
Position
We are seeking a Scientist to lead downstream process development for the mRNA Engineering team. In this role, you will design, optimize, and scale purification processes for mRNA drug substance.
This is a hands-on, lab-based role that spans program process development and platform engineering. It is ideal for a scientist who enjoys solving purification challenges and scaling processes in a dynamic, fast-paced environment.
Support tech transfer and CDMO manufacturing
- Perform tech transfer of downstream processes to CDMOs
- Act as person in plant during CDMO manufacturing runs
- Support process troubleshooting and deviation investigations at CDMOs
Documentation and collaboration
- Maintain organized experimental records in Electronic Lab Notebooks
- Author development SOPs and technical development reports
- Present experiment results at team meetings
Requirements
- Ph.D. in analytical chemistry, biochemistry, molecular biology, chemical engineering, or a related field with 0-3 years of relevant industry experience, or an M.S. with 5+ years or B.S. with 7+ years of relevant industry experience
- Hands-on experience developing downstream purification processes for nucleic acids or other biologics
- Hands-on experience with tangential flow filtration (TFF)
- Experience operating ÄKTA chromatography systems
- Ability to independently design, execute, and troubleshoot experiments
- Ability to analyze and present complex data sets
- Strong technical writing skills
- Excellent communication and organizational skills
Nice to have
- Experience with traditional nucleic acid purification methods (e.g., desalting, precipitation, size-exclusion)
- Experience with plasmid DNA purification
- Experience with Design of Experiments (DoE) and statistical data analysis
- Experience implementing automated or high-throughput purification workflows
- Experience with process transfer to CDMOs
- General understanding of cGMP and phase-appropriate process development
- Familiarity with mRNA analytics such as HPLC, CGE, and dsRNA ELISA
Benefits
NewLimit offers generous benefits to ensure our team can focus on our mission:
- Health, dental, and vision insurance
- 401(k) with company match
- Paid parental leave
- Industry-leading paid time off (PTO) - 20 days/year for all employees + holidays
- Meals and snacks on-site
Salary Range
$120,000-155,000*. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO.
*This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.
About NewLimit
NewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.
As a member of our team, you will
Develop downstream purification processes
- Design, execute, and analyze process development studies for mRNA purification
- Act as the downstream lead for CMC program teams
- Help design and implement automated downstream workflows for high-throughput purification of research-grade mRNA
- Support execution of research-grade mRNA production runs for discovery and preclinical studies, as needed
- Support process scale-up from bench to pilot scale, as needed
- Evaluate emerging purification technologies and chromatography resins
From NewLimit's careers page, first listed on Rolev.ai on October 21, 2026. Rolev.ai is not the employer.
How Rolev.ai helps with this application
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More at NewLimit
All NewLimit jobsCommon questions
What is the salary for the Scientist, mRNA Downstream Purification role at NewLimit?
The Scientist, mRNA Downstream Purification posting at NewLimit states compensation of $120,000 – $155,000 per year. It is listed as a full-time position. Final pay may depend on location, experience, and interview evaluation on NewLimit's official career site.
Where is the Scientist, mRNA Downstream Purification job at NewLimit located?
This Scientist, mRNA Downstream Purification position at NewLimit is located in South San Francisco, CA (On-site). Always check NewLimit's application page for specific state eligibility or relocation policies.
What qualifications are required for Scientist, mRNA Downstream Purification at NewLimit?
For the Scientist, mRNA Downstream Purification role, NewLimit highlights a doctorate; experience with tangential flow filtration, ÄKTA chromatography, process development. Rolev.ai can score your existing resume against these requirements and show any skill gaps before you apply.
How do I apply for the Scientist, mRNA Downstream Purification position at NewLimit?
This listing links directly to NewLimit's Greenhouse application page. You can apply directly on NewLimit's site, or use Rolev.ai to check your resume fit, generate a zero-hallucination tailored resume and cover letter for this posting, and autofill the Greenhouse application form in 1 click with the Rolev.ai Chrome extension. You always review the form and press Submit yourself.