Scientist/Senior Scientist
- Pay
- $130,000 – $180,000 per year
- Location
- South San Francisco, CA · On-site
- Job type
- Full-time
- Level
- Mid-level
- Experience
- 5+ years
- Education
- Doctorate
- Listed
- 30 days ago
Skills & highlights for this role
- primary cell isolation
- mouse models
- transgenic manipulation of primary cells
Also useful
- single cell genomics
- pooled CRISPR screening
- preclinical study design
Stated benefits & perks
- Health
- Dental
- Vision
- 401k match
- Parental leave
Position
NewLimit is seeking an scientist with experience in discovery biology to join our Vascular therapeutic team. Our Vascular program is developing reprogramming medicines to restore youthful function in aged endothelial cells for the treatment of renal, cardiometabolic, and cognitive diseases.
Your role will focus on developing and deploying assays to measure the functional decline that occurs in endothelial cells with age. You will collaborate closely with our technology teams to help create the first reprogramming medicines for the vascular tissue that supports all others.
In your role as a Scientist, you will
- Develop functional assays and pre-clinical models to measure endothelial cell function
- Collaborate with our Functional Genomics and Predictive Modeling teams to test reprogramming hypotheses at scale
- Measure the impact of mRNA reprogramming medicines on endothelial cell function
- Engineer in vivo nucleic acid delivery methods for endothelial cells
- Analyze and interpret experimental data to drive pre-clinical decision making
Requirements
- Ph.D. in cell biology, molecular biology, biochemistry or a related field or equivalent industry experience (5+ years)
- Experience with primary cell isolation and functional characterization
- Experience working with mouse models (e.g. kidney, cardiovascular, or cognitive disease models)
- Experience with transgenic manipulation of primary cells either ex vivo or in vivo (e.g. using viral vectors, nucleic acid delivery)
Nice to have
- History of contributing to a drug development program at the pre-clinical or clinical development stage
- Experience leading the design and execution of pre-clinical studies in mouse models
- Experience with single cell genomics methods
- Experience with pooled screening approaches using bulk or single cell read-outs (e.g. CRISPR fitness screens, Perturb/CROP-seq)
Benefits
NewLimit offers generous benefits to ensure our team can focus on our mission:
- Health, dental, and vision insurance
- 401(k) with company match
- Paid parental leave
- Industry-leading paid time off (PTO) - 20 days/year for all employees + holidays
- Meals and snacks on-site
Salary Range
$130,000 to $180,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO.
About NewLimit
NewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.
From NewLimit's careers page, first listed on Rolev.ai on October 10, 2026. Rolev.ai is not the employer.
How Rolev.ai helps with this application
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Common questions
What is the salary for the Scientist/Senior Scientist role at NewLimit?
The Scientist/Senior Scientist posting at NewLimit states compensation of $130,000 – $180,000 per year. It is listed as a full-time position. Final pay may depend on location, experience, and interview evaluation on NewLimit's official career site.
Where is the Scientist/Senior Scientist job at NewLimit located?
This Scientist/Senior Scientist position at NewLimit is located in South San Francisco, CA (On-site). Always check NewLimit's application page for specific state eligibility or relocation policies.
What qualifications are required for Scientist/Senior Scientist at NewLimit?
For the Scientist/Senior Scientist role, NewLimit highlights 5+ years of relevant experience; a doctorate; experience with primary cell isolation, mouse models, transgenic manipulation of primary cells. Rolev.ai can score your existing resume against these requirements and show any skill gaps before you apply.
How do I apply for the Scientist/Senior Scientist position at NewLimit?
This listing links directly to NewLimit's Greenhouse application page. You can apply directly on NewLimit's site, or use Rolev.ai to check your resume fit, generate a zero-hallucination tailored resume and cover letter for this posting, and autofill the Greenhouse application form in 1 click with the Rolev.ai Chrome extension. You always review the form and press Submit yourself.