Scientist/Sr. Scientist, Chemical Biology

tl;dr

General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.

We are seeking a first-rate chemical biologist to help us pioneer this uncharted frontier of drug discovery.

The Position

We are seeking an experienced chemical biologist with medicinal chemistry training to be a founding member of our Chemistry/Drug Discovery Team. In this position, you will work with both our Chemistry and Platform Teams in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.

Your responsibilities will include

supervising synthetic efforts with our CROs, designing, performing, and analyzing in cellulo assays, designing and optimizing first-in-class bifunctional molecules, collaborating with our Drug Discovery and IP team on patent applications, providing input for mechanistic studies on lead drug molecules, and spearheading forays into new disease areas.

About You

• High Agency. Initiative, independence, and self-accountability are some of our most valued traits.
• Enthusiastic. We love people who are excited about what they are doing and are generally attempting to build a high-energy team.

• Intensity and Grit.
• Early-stage startups are hard.
• Drug discovery is doubly so.
• We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.

• Prosocial.
• We are here to create life-saving medicines for the patients who need it most.
• You should be, too.

Qualifications & Nice-To-Haves

• PhD in Chemical Biology, Medicinal Chemistry, Pharmacology, or related field.
• Chemical Biology with Medicinal Chemistry experience required.
• Industry experience is desirable, but the ability to work hard and learn fast is more important to us.
• Deep understanding of small-molecule drug discovery and its relationship to human disease.
• Able to work fluently at the interface of chemistry and biology.
• Top-notch written and oral communication skills.
• Strong experience with:
• Designing, synthesizing, and optimizing induced proximity medicines (e.g. PROTACs or other IPMs)
• Contributing to hit-to-lead and lead optimization studies
• Med-chem optimizations: SAR, PK/PD, strong understanding of DMPK
• Experience with chemical biology techniques such as mammalian cell culture and cell-based assays (e.g., cytotoxicity assays, transfections, stable cell line generation, co-immunoprecipitation), and PPI assays (e.g., BRET, APEX/BioID, AlphaScreen)
• Nice to have:
• Proficiency in HTS and phenotypic assay development
• Proteomics experience: PTM analysis, chemo-proteomic target deconvolution, etc.
• Computational or molecular dynamics drug discovery experience
• DEL experience
• Experience managing others, especially synthetic chemistry CRO teams
• Prior experience on teams that have successfully advanced research to the clinic

Benefits

• Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.
• Top tier medical, dental, and vision coverage + One Medical membership.
• 401(k) retirement plans.
• Education and health/fitness incentive programs.
• Meditation retreats-do a ten-day Vipassana retreat without counting towards vacation days.
• Reading budget! We will buy you books.
• Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.