Senior Director, Clinical Translational Scientist
- Pay
- $279,450 – $302,220 per year
- Location
- Lexington, MA · On-site
- Job type
- Full-time
- Level
- Director
- Experience
- 12+ years
- Education
- Doctorate
- Listed
- 31 days ago
Skills & highlights for this role
- translational medicine
- biomarker development
- PK/PD modeling
- clinical drug development
- IND-enabling studies
Also useful
- model-informed drug development
- immunology
Responsibilities (including, but not limited to)
- Lead development and execution of integrated translational medicine strategies across clinical development programs.
- Develop and continually refine biomarker and clinical pharmacology plans to support target engagement, proof-of-mechanism, proof-of-biology, dose optimization, and patient selection.
- Translate emerging biological, pharmacological, and clinical data into actionable development recommendations.
- Identify and prioritize translational milestones to inform key portfolio decisions and stage-gate transitions.
- Define biomarker strategies spanning exploratory, pharmacodynamic, predictive, prognostic, and diagnostic biomarkers.
- Partner with bioanalytical and laboratory teams to develop, validate, and implement clinical biomarker assays.
- Lead interpretation of biomarker, PK/PD, and clinical datasets to generate insights regarding mechanism of action, treatment response, and resistance pathways.
- Support implementation of innovative technologies and emerging translational approaches.
- Contribute to study design, protocol development, endpoint selection, statistical analysis planning, and clinical study execution.
- Build productive relationships with internal stakeholders, external partners, CROs, academic investigators, key opinion leaders, and laboratory vendors.
- Contribute translational components to regulatory submissions including INDs, briefing documents, and marketing applications.
- Support interactions with health authorities related to biomarkers, companion diagnostics, and translational strategy.
- Maintain awareness of emerging scientific advances and competitive developments within immunology, inflammation, cardiovascular disease, and related therapeutic areas.
- Foster a collaborative, patient-focused, and scientifically rigorous culture.
- Contribute to departmental strategy, capability building, and organizational development.
Standout Skills for Impact
- Expertise in developing and executing translational medicine and biomarker strategies across clinical development programs.
- Proven ability to integrate scientific, biomarker, and clinical data to deepen the understanding of patient populations and drug mechanism of action in patients.
- Experience leading and influencing cross-functional teams across Research, Clinical Development, Regulatory Affairs, and Medical Affairs.
- Demonstrated success supporting programs from early clinical development through proof-of-concept and late-stage studies.
Qualifications and Experience
- PhD, PharmD, MD, or MD/PhD in Immunology, Translational Medicine, Pharmacology, Molecular Biology, Clinical Science, or related discipline.
- Advanced clinical development and translational medicine expertise strongly preferred.
- 12+ years of biotechnology or pharmaceutical industry experience, with significant experience in translational medicine and clinical drug development.
- Demonstrated success supporting programs from IND through proof-of-concept and/or late-stage clinical development.
- Experience in immunology, inflammation, cardiovascular disease, rare disease, or related therapeutic areas preferred.
- Working knowledge of biomarker development, clinical pharmacology, PK/PD relationships, and model-informed drug development.
- Experience supporting regulatory interactions and submissions.
Additional information
Compensation decisions are based on objective criteria including role responsibilities, experience/qualifications, internal equity, geographic location, and external market benchmarks.
Pay Range $279,450—$302,220 USD
Kiniksa does not accept unsolicited resumes from staffing agencies or search firms. Any resumes submitted without a signed agreement will be considered property of Kiniksa, and no fees will be paid.
About Kiniksa Pharmaceuticals
Kiniksa Pharmaceuticals is a commercial-stage biopharmaceutical company developing and commercializing novel therapies for diseases with unmet need, with a focus on cardiovascular indications.
With deep expertise in immunology and inflammation, Kiniksa is advancing a growing portfolio of approved and investigational medicines, anchored by its lead product, ARCALYST®, the first and only FDA-approved therapy for recurrent pericarditis. Grounded in rigorous science and bold innovation, the company fosters a highly collaborative, patient-first culture led by accomplished life sciences leaders.
At Kiniksa, talented individuals are trusted and empowered to make a real impact-shaping the future of medicine while improving the lives of patients who need it most.
Kiniksa is seeking an accomplished and strategic Senior Director, Clinical Translational Scientist reporting to GVP, Research & Non-Clinical Development to play a critical leadership role in advancing clinical-stage development programs from early clinical development through proof-of-concept and registrational studies. The successful candidate will drive translational strategies that connect disease biology, mechanism of action, biomarkers, pharmacology, and clinical outcomes to enable data-driven development decisions.
This individual will serve as a key scientific leader across multidisciplinary teams, integrating insights from Research, Clinical Development, Clinical Pharmacology, Bioanalysis, Biostatistics, Regulatory Affairs, and Medical Affairs to maximize the probability of technical and regulatory success across the portfolio. The role requires deep expertise in translational medicine, biomarker strategy, immunology, and clinical drug development.
This role is based in our Lexington, MA office. Our office-based employees follow an onsite schedule of 5 days in the office (Mon-Fri)
Equal opportunity and legal notices
Kiniksa is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, transgender status, age, genetics, national origin, protected veteran status, or disability status, or any other legally protected category. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
From Kiniksa Pharmaceuticals's careers page, first listed on Rolev.ai on October 10, 2026. Rolev.ai is not the employer.
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What is the salary for the Senior Director, Clinical Translational Scientist role at Kiniksa Pharmaceuticals?
The Senior Director, Clinical Translational Scientist posting at Kiniksa Pharmaceuticals states compensation of $279,450 – $302,220 per year. It is listed as a full-time position. Final pay may depend on location, experience, and interview evaluation on Kiniksa Pharmaceuticals's official career site.
Where is the Senior Director, Clinical Translational Scientist job at Kiniksa Pharmaceuticals located?
This Senior Director, Clinical Translational Scientist position at Kiniksa Pharmaceuticals is located in Lexington, MA (On-site). Always check Kiniksa Pharmaceuticals's application page for specific state eligibility or relocation policies.
What qualifications are required for Senior Director, Clinical Translational Scientist at Kiniksa Pharmaceuticals?
For the Senior Director, Clinical Translational Scientist role, Kiniksa Pharmaceuticals highlights 12+ years of relevant experience; a doctorate; experience with translational medicine, biomarker development, PK/PD modeling, clinical drug development, IND-enabling studies. Rolev.ai can score your existing resume against these requirements and show any skill gaps before you apply.
How do I apply for the Senior Director, Clinical Translational Scientist position at Kiniksa Pharmaceuticals?
This listing links directly to Kiniksa Pharmaceuticals's Greenhouse application page. You can apply directly on Kiniksa Pharmaceuticals's site, or use Rolev.ai to check your resume fit, generate a zero-hallucination tailored resume and cover letter for this posting, and autofill the Greenhouse application form in 1 click with the Rolev.ai Chrome extension. You always review the form and press Submit yourself.