Senior Director, GCS - Rare Endocrinology - Palsonify

General Summary

The Senior Director Global Commercial Strategy (GCS), Rare Endocrinology - PALSONIFY will serve as the global commercial lead for Palsonify. Reporting to the Vice President, GCS - Rare Endocrinology, this leader will own the integrated commercial strategy for acromegaly and help translate the potential of Palsonify into a differentiated global commercialization plan.

Palsonify joined the Vertex portfolio through the acquisition of Crinetics Pharmaceuticals and is currently approved and marketed in the United States and approved in the European Commission. The Senior Director will lead the global commercial market assessment for acromegaly in partnership with the international team, drive global launch preparation, shape evidence generation and publication priorities, and develop the lifecycle management strategy for Palsonify.

Key Duties & Responsibilities

• Serve as the global commercial lead for Palsonify * Lead the commercial market assessment for acromegaly, including epidemiology, patient segmentation, unmet need, treatment patterns, patient and HCP journeys, competitive dynamics, access considerations, and global market potential.
• Develop and maintain the commercial strategy and target product profile for Palsonify in acromegaly, defining the patient populations, differentiation, value drivers, evidence requirements, and critical success factors required to win.
• Provide commercial leadership into clinical development and real-world evidence plans, ensuring populations, endpoints, comparators, and evidence generation support meaningful differentiation and commercialization objectives.
• Lead commercial development activities, including primary market research, forecasting, competitive intelligence, scenario planning, opportunity assessments, and investment recommendations.
• Leverage the US brand strategy to develop the integrated global brand strategy for Palsonify in acromegaly, including positioning, strategic narrative, and value proposition
• Lead global launch preparation, including launch strategy, market development, regional and country alignment, learning agenda, readiness milestones, cross-functional deliverables, and progress against critical success factors.
• Partner closely with regional and country Commercial teams to ensure the global strategy reflects market realities and can be translated into effective local launch plans.
• Own the global lifecycle management strategy for Palsonify in acromegaly, identifying opportunities to strengthen differentiation, expand patient impact, optimize the product profile, and maximize long-term value.
• Partner across Development, Medical, Regulatory, Value & Access, HEOR, Analytics & Market Research, Finance, Manufacturing and Supply Chain, Patient Advocacy, and regional Commercial teams to deliver an aligned development and commercialization plan.
• Communicate clear, evidence-based recommendations to senior leaders and governance bodies, including key assumptions, trade-offs, risks, opportunities, and decisions required.
• Build strong external understanding through engagement with patients, caregivers, healthcare professionals, advocacy organizations, and other relevant stakeholders, consistent with applicable requirements.
• Lead and develop team members and external partners as the program advances, fostering strategic rigor, collaboration, accountability, and urgency.

Education and Experience

• Minimum of a Bachelor's degree in business, marketing, life sciences, healthcare, or a related field.
• Advanced degree such as an MBA, M.S., MPH, Pharm.D., Ph.D., M.D., or other relevant qualification preferred.
• Significant biopharmaceutical commercial experience, including global commercial strategy, new product planning, brand strategy, or marketing leadership.
• Demonstrated experience shaping pipeline or pre-launch assets and translating market insight into development strategy, target product profiles, evidence requirements, and investment decisions.Strong experience leading commercial opportunity assessments, market research, forecasting, competitive assessment, and scenario planning.
• Demonstrated global launch-planning experience, including development of brand strategy, positioning, value proposition, market-development priorities, and launch-readiness plans.
• Experience developing lifecycle strategies that connect clinical development, evidence generation, label opportunities, formulation, and commercialization priorities.
• Experience in rare disease, endocrinology, specialty markets, or another complex market with concentrated customers and significant patient-identification challenges strongly preferred.

Additional information

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range

$240,000 - $360,000

Disclosure Statement

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation: Hybrid-Eligible Or On-Site Eligible

In this Hybrid-Eligible role, you can choose to be designated as

• Hybrid: work remotely up to two days per week; or select
• On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Hybrid

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at