Senior/Principal Associate Scientist, Mammalian Physiology
- Pay
- $130,000 – $161,000 per year
- Location
- South San Francisco, CA
- Listed
- Today
Position Description
We are seeking a Senior/Principal Associate Scientist to join an interdisciplinary, collaborative team working at the intersection of mammalian stress response pathways and disease. The ideal candidate will be a skilled experimentalist with exceptional critical thinking skills, strong communication skills across cross-functional teams, and a strong history of productivity in fast-paced work environments. This person will be able to work both independently and collaboratively and will be detail-oriented, organized, adaptable and self-motivated.
Key Responsibilities
- Manage and coordinate in vivo studies, in collaboration with the Research Physiology team
- Independently conduct smaller in vivo studies
- Sample preparation and management and execution of downstream assays
- Lead development and execution of primary cell culture assays
- Effectively communicate experimental results and project progress in various forums such as lab meetings
Position Requirements
- BS/MS degree in physiology, biology, genetics, neuroscience or a related field, with 8+ years (BS) or 6+ years (MS) of extensive experience with in vivo mammalian model systems
- Proficiency in mammalian in vivo experiments and primary cell isolation and culture; familiarity with complex co-culture systems and/or organoids preferred
- Experienced in deploying biochemical, cellular and molecular assays, histology and immunofluorescence
- Excellent written and oral communication skills and highly organized with ability to multi-task
- Demonstrated ability to analyze and interpret complex data
- Versatile experimentalist with a track record of learning new skills quickly
- Skilled collaborator who is able to work closely with different teams to achieve project goals
- Ability to independently plan, execute and analyze experiments to meet time-sensitive goals
- Basic statistical skills required
- Preference for prior experience working with data software such as Prism
- Must be willing to work on site 5 days a week
Pay and benefits
The estimated base salary range for this role is $130,000 - $161,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.
Who We Are
Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico's highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.
From Calico Life Sciences's careers page, first listed on Rolev.ai on November 12, 2026. Rolev.ai is not the employer.
How Rolev.ai helps with this application
Rolev.ai is a job search and application tool for US job seekers. For this Senior/Principal Associate Scientist, Mammalian Physiology role at Calico Life Sciences, it shows how your resume fits, tailors your resume to the posting, and prepares the application for you to review.
See how you fit
Openings from employer career sites are ranked against your whole resume—and searchable inside Claude, ChatGPT, and Cursor via Rolev.ai MCP.
Tailor without inventing
Every change to your resume is checked against your original. New experience goes in only with your yes—zero fabricated claims.
Draft the full kit
Tailored and Full Match resumes, role-specific cover letters, and answers to employer screening questions are prepared in seconds.
1-Click Extension Autofill
The Chrome extension fills the employer's Greenhouse, Workday, Lever, or Ashby form in 1 click. You review it and press Submit.
Similar roles
- Senior Principal Engineer, Mechanical EngineeringNevada State Assembly · US > Arizona > Phoenix
- Senior Principal StatisticianAtricure, Inc. · Mason, OH
- Senior Principal Software Engineer, Cloud ArchitectureCargurus · Boston, MA
- Senior Principal Full Stack EngineerDigicert · Sterling, VA
- Senior Principal, Business ManagementInovalon · Remote -
- Senior Principal Demand Generation - ExpansionZoominfo · Waltham, MA
Common questions
What is the salary for the Senior/Principal Associate Scientist, Mammalian Physiology role at Calico Life Sciences?
The Senior/Principal Associate Scientist, Mammalian Physiology posting at Calico Life Sciences states compensation of $130,000 – $161,000 per year. Final pay may depend on location, experience, and interview evaluation on Calico Life Sciences's official career site.
Where is the Senior/Principal Associate Scientist, Mammalian Physiology job at Calico Life Sciences located?
This Senior/Principal Associate Scientist, Mammalian Physiology position at Calico Life Sciences is located in South San Francisco, CA. Always check Calico Life Sciences's application page for specific state eligibility or relocation policies.
How do I apply for the Senior/Principal Associate Scientist, Mammalian Physiology position at Calico Life Sciences?
This listing links directly to Calico Life Sciences's Greenhouse application page. You can apply directly on Calico Life Sciences's site, or use Rolev.ai to check your resume fit, generate a zero-hallucination tailored resume and cover letter for this posting, and autofill the Greenhouse application form in 1 click with the Rolev.ai Chrome extension. You always review the form and press Submit yourself.