Senior Research Associate, High-Throughput RNA Production
- Pay
- $75,000 – $95,000 per year
- Location
- Cambridge, MA · On-site
- Job type
- Full-time
- Level
- Senior
- Experience
- 2+ years
- Listed
- 31 days ago
Skills & highlights for this role
- plasmid cloning
- in vitro transcription
- HPLC analysis
Also useful
- Hamilton liquid handling
- Benchling
- SnapGene
The Role
The Senior Research Associate, high-throughput (HTP) RNA production, serves an important role in generating RNAs to advance Sail's first-in-class programmable circular RNA technology (Endless RNA™ or eRNA). This role will carry out end-to-end process of high-throughput RNA production, from template plasmid cloning to RNA generation and clean up.
The successful candidate is organized, attentive to details, a fast learner with a strong sense of responsibility who takes pride in his/her work. The team looks forward to helping you strive in this exciting and fast-paced environment to make a real-world impact on patients' lives.
Responsibilities
- Perform high-throughput cloning of plasmid constructs and RNA generation through in vitro transcription (IVT)
- Determine circularization efficiency and impurity levels by running analytic assays
- Coordinate DNA synthesis and scale-up orders with external vendors
- Manage raw material and RNA inventories
- Collaborate with automation engineer to improve process workflow
- Maintain detailed documentation in electronic lab notebooks
- Present findings clearly to platform teams and contribute to scientific discussions and decision-making
Qualifications
- B.S. in Life Sciences, Chemistry, Engineering, or a related field with 2+ years of relevant full-time industry or academic research experience, or M.S. in Life Sciences
- Ability to manage multiple tasks at once efficiently
- Strong collaborative spirit and communication skills
- Excellent record keeping
Preferred Qualifications
- Experience in molecular biology including cloning, RNA production and purification
- Familiarity with high-performance liquid chromatography (HPLC) or other column-based purification/analytic methods
- Experience with automated liquid handling systems (e.g., Hamilton) and high-throughput laboratory workflows
- Experience using data analysis and information management tools, such as Excel, Graphic Prism, SnapGene, Benchling
- Experience in inventory management
About Sail
Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail's platform combines first-in-class programmable circular RNA technology (Endless RNA™ or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time.
By leveraging cutting-edge eRNA and nanoparticle deployment technology, Sail is also making unparalleled use of AI techniques to identify and design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering.
Equal opportunity and legal notices
Sail Biomedicines is an Equal Opportunity Employer. Sail does not discriminate based on race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law.
From Sail Biomedicines's careers page, first listed on Rolev.ai on October 10, 2026. Rolev.ai is not the employer.
How Rolev.ai helps with this application
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Common questions
What is the salary for the Senior Research Associate, High-Throughput RNA Production role at Sail Biomedicines?
The Senior Research Associate, High-Throughput RNA Production posting at Sail Biomedicines states compensation of $75,000 – $95,000 per year. It is listed as a full-time position. Final pay may depend on location, experience, and interview evaluation on Sail Biomedicines's official career site.
Where is the Senior Research Associate, High-Throughput RNA Production job at Sail Biomedicines located?
This Senior Research Associate, High-Throughput RNA Production position at Sail Biomedicines is located in Cambridge, MA (On-site). Always check Sail Biomedicines's application page for specific state eligibility or relocation policies.
What qualifications are required for Senior Research Associate, High-Throughput RNA Production at Sail Biomedicines?
For the Senior Research Associate, High-Throughput RNA Production role, Sail Biomedicines highlights 2+ years of relevant experience; experience with plasmid cloning, in vitro transcription, HPLC analysis. Rolev.ai can score your existing resume against these requirements and show any skill gaps before you apply.
How do I apply for the Senior Research Associate, High-Throughput RNA Production position at Sail Biomedicines?
This listing links directly to Sail Biomedicines's Greenhouse application page. You can apply directly on Sail Biomedicines's site, or use Rolev.ai to check your resume fit, generate a zero-hallucination tailored resume and cover letter for this posting, and autofill the Greenhouse application form in 1 click with the Rolev.ai Chrome extension. You always review the form and press Submit yourself.