Senior Research Associate, In Vivo Pharmacology

About the role

Why this role matters.

Our gene editing programs for neurodegenerative diseases can only advance if in vivo studies show that an editor works in a living animal. This role carries those studies from dosing through tissue collection to the molecular readout. The data you generate feeds the preclinical and IND-enabling work that decides whether a program moves forward.

This role reports to the Senior Scientist, In Vivo Pharmacology. It is on-site in Cambridge, typically 4-5 days per week.

What you'll own.

• Run in vivo pharmacology studies in rodents, including dosing, monitoring, clinical observations, blood collection, tissue harvest, and necropsy.
• Set up and schedule studies, and coordinate between the laboratory and the animal facility.
• Process tissues and biological samples, and isolate DNA, RNA, and protein for molecular, biochemical, and pharmacodynamic analysis.
• Run assays such as qPCR/ddPCR, RT-qPCR, Western blot, Simple Western/Jess, ELISA, or RNAscope.
• Analyze, interpret, and graph study and assay data in GraphPad Prism and other analysis tools.
• Present findings, study progress, and data summaries to project teams and cross-functional collaborators.
• Keep study records, sample inventories, and protocols accurate and current.

What you've done.

• Bachelor's degree in pharmacology, biology, neuroscience, molecular biology, or a related field with 3+ years of industry experience, or a master's degree with 1+ year.
• Has run in vivo rodent studies hands-on, including dosing, monitoring, blood collection, tissue harvest, and necropsy.
• Has dosed rodents by intravenous, retro-orbital, or comparable routes.
• Has processed animal tissues and biological samples for molecular, biochemical, or pharmacodynamic endpoints.
• Has run molecular and biochemical assays such as qPCR/ddPCR, RT-qPCR, Western blot, Simple Western/Jess, ELISA, or RNAscope; flow cytometry experience preferred.
• Has managed samples and timelines across more than one study at a time.
• Has supported IND-enabling studies (preferred).

What you'll get.

The anticipated base salary range for this role is $85,000-$95,000. Actual pay depends on relevant experience, skills, education, internal equity, and other job-related factors.

Every employee is eligible for a bonus and new hire equity. We pay about 90% of medical, dental, and vision premiums and fund the full deductible on our HSA plan. You'll also get 12 weeks of parental leave at full pay, paid parking or transit, a 401(k) match, and discretionary time off.