Senior Research Associate, Preclinical Pharmacology

About the role

Run in vivo studies that move Nurix's degrader programs toward the clinic. You'll execute mouse efficacy, PK/PD, and mechanism-of-action studies in oncology and inflammation models and generate the Western blot and flow cytometry data that show how our molecules work.

The Opportunity

• Join the Research - Preclinical Pharmacology team as a full-time, onsite, hands-on member, reporting to a Scientist / Principal Scientist, Preclinical Pharmacology
• Perform mouse handling and in-life procedures, including dosing by oral (PO), intraperitoneal (IP), subcutaneous (SC), and intravenous (IV) routes, tumor cell implantation, tumor and body-weight measurements, and in-life and terminal blood collection
• Execute PK/PD, tolerability, and efficacy studies in oncology xenograft/syngeneic models and in murine models of inflammation, under the direction of study leads
• Prepare and formulate test articles and vehicles for dosing; monitor animal health, document observations, and escalate adverse events promptly
• Perform necropsy and collect, process, and bank tissues and blood for downstream biomarker and pharmacodynamic analyses
• Prepare tissue and cell lysates and perform Western blotting (including quantitative and automated capillary formats) to measure target degradation and pathway modulation
• Develop, run, and analyze multi-color flow cytometry panels for immune and tumor-cell phenotyping from blood, spleen, tumor, and other tissues
• Maintain and expand cell lines using sterile cell culture technique; support cell-based assays and the generation of cells for in vivo implantation
• Record experiments accurately and in a timely manner in the electronic lab notebook; analyze, graph, and summarize data and present results at team meetings
• Collaborate with Biology, Chemistry, DMPK, and Translational teams to design studies and troubleshoot models and assays
• Adhere to IACUC protocols, animal welfare regulations, and laboratory safety requirements, and maintain required training and certifications
• Contribute to the optimization and qualification of new models and assays and to the training of junior team members
• Maintain laboratory equipment and supplies and support vivarium coordination, including occasional weekend or off-shift study coverage; other essential duties as assigned; minimal travel (Salary Range: $131,400 - $139,900

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate's relevant experience, technical expertise, and how their background aligns with the role's requirements.

Location: Onsite - Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view