Senior Scientist (Drug Metabolism & Pharmacokinetics)
- Pay
- $124,300 – $230,900 per year
- Location
- South San Francisco, CA · On-site
- Job type
- Full-time
- Level
- Senior
- Experience
- 2+ years
- Education
- Doctorate
- Listed
- 21 days ago
Skills & highlights for this role
- pharmacokinetics
- ADME
- PK/PD modeling
- PBPK modeling
Also useful
- Lipinski's Rule-of-5 beyond modalities
- IND-enabling development
About the role
The Drug Metabolism & Pharmacokinetics (DMPK) department at Genentech is seeking a highly motivated leader who will be supporting small molecule projects in discovery and development.
The DMPK group is dedicated to enabling the discovery, development and commercialization of safe and effective medicines by elucidating the absorption, distribution, metabolism, excretion and pharmacokinetic properties of traditional small molecule and emerging modality drug candidates.
We accomplish this through the application of state-of-the-art technologies and sciences of bioanalysis, drug metabolism, drug transport and pharmacokinetics.
The DMPK group works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to optimize leads, select clinical candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.
The Opportunity
The individual would lead the DMPK strategy, design and oversee non-clinical studies in a highly collaborative project team environment. Specifically, the individual will be involved in the following activities as part of their role:
- Serve as the DMPK representative on multidisciplinary project teams and communicate recommendations to project teams.
- Lead DMPK strategy and author or review relevant sections of regulatory briefing packages/filings.
- Design, oversee, interpret and integrate in vitro and in vivo ADME, PK and translate nonclinical data into human PK and dose predictions.
- Identify DMPK-related risks, and develop mitigation strategies.
Who You Are
- PhD in pharmacokinetics, drug metabolism, pharmaceutical sciences or related discipline.
- At least 2 years of relevant pharmaceutical industry experience as a DMPK project leader.
- Strong knowledge of ADME, PK, and the integration of DMPK data into discovery and development decisions.
- Experience designing, interpreting and integrating nonclinical DMPK studies.
- Ability to communicate complex scientific data, uncertainties and recommendations clearly to multidisciplinary teams and senior stakeholders.
Preferred
- Experience as a member/leader of multi-functional project teams supporting diverse modalities (small/large molecules, peptides, degraders, conjugates etc.), in particular, those outside Lipinski’s Rule-of-5.
- Experience supporting programs through candidate selection, IND-enabling development, clinical development or regulatory interactions.
- Hands-on experience with PK/PD modeling and/or PBPK modeling using relevant modeling and simulation platforms are highly desired.
- Together, we’ll advance along the whole patient journey with the aspiration to prevent, stop and cure diseases.
- This position does offer domestic relocation.
Pay and benefits
The expected salary range for this position based on the primary location of San Francisco, CA is 124,300.00 - 230,900.00 USD. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.
This position also qualifies for the benefits detailed at the link provided below.
Benefits
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Equal opportunity and legal notices
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
From Roche's careers page, first listed on Rolev.ai on October 20, 2026. Rolev.ai is not the employer.
How Rolev.ai helps with this application
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Common questions
What is the salary for the Senior Scientist (Drug Metabolism & Pharmacokinetics) role at Roche?
The Senior Scientist (Drug Metabolism & Pharmacokinetics) posting at Roche states compensation of $124,300 – $230,900 per year. It is listed as a full-time position. Final pay may depend on location, experience, and interview evaluation on Roche's official career site.
Where is the Senior Scientist (Drug Metabolism & Pharmacokinetics) job at Roche located?
This Senior Scientist (Drug Metabolism & Pharmacokinetics) position at Roche is located in South San Francisco, CA (On-site). Always check Roche's application page for specific state eligibility or relocation policies.
What qualifications are required for Senior Scientist (Drug Metabolism & Pharmacokinetics) at Roche?
For the Senior Scientist (Drug Metabolism & Pharmacokinetics) role, Roche highlights 2+ years of relevant experience; a doctorate; experience with pharmacokinetics, ADME, PK/PD modeling, PBPK modeling. Rolev.ai can score your existing resume against these requirements and show any skill gaps before you apply.
How do I apply for the Senior Scientist (Drug Metabolism & Pharmacokinetics) position at Roche?
This listing links directly to Roche's Workday application page. You can apply directly on Roche's site, or use Rolev.ai to check your resume fit, generate a zero-hallucination tailored resume and cover letter for this posting, and autofill the Workday application form in 1 click with the Rolev.ai Chrome extension. You always review the form and press Submit yourself.