Senior Scientist, In Vitro and In Vivo Pharmacology
- Pay
- $166,738 – $174,397 per year
- Location
- Lexington, MA · On-site
- Job type
- Full-time
- Level
- Director
- Experience
- 5+ years
- Education
- Doctorate
- Listed
- 31 days ago
Skills & highlights for this role
- in vitro pharmacology
- cell-based assays
- pharmacodynamic assays
- biologics characterization
Also useful
- translational medicine
Responsibilities (including, but not limited to)
- Design, execute, and interpret in vitro pharmacology studies to support target validation, lead characterization, and clinical-stage development programs.
- Develop mechanistic assays evaluating target engagement, receptor occupancy, signaling pathways, cytokine modulation, immune cell activation, and pharmacodynamic responses.
- Establish and optimize cell-based and biochemical assays using primary cells, immortalized cell lines, co-culture systems, and in vivo disease-relevant models.
- Generate data packages that support candidate selection, indication prioritization, dose selection rationale, and clinical biomarker strategies.
- Identify emerging targets and pathways associated with protease driven and immune-mediated disease.
- Serve as a scientific representative on project teams, contributing to research strategy, development plans, and decision-making.
- Collaborate with external CROs, academic investigators, and clinical collaborators.
- Present scientific findings to senior leadership and project governance teams.
- Author technical reports, study protocols, scientific publications, regulatory support documents, and presentations.
Standout Skills for Impact
- Strong experience with in vitro and in vivo pharmacology studies.
- Expertise in immunology, inflammation, and biologic drug development.
- Hands-on experience developing and optimizing cell-based and mechanistic assays.
- Ability to analyze complex scientific data and translate findings into actionable insights.
- Strong collaboration and communication skills within cross-functional drug development teams.
Qualifications and Experience
- PhD in Pharmacology, Immunology, Cell Biology, Molecular Biology, Biomedical Sciences, or related discipline.
- Typically 5+ years of relevant biotechnology or pharmaceutical industry experience.
- Demonstrated experience supporting discovery and translational development of biologic therapeutics.
- Experience working within cross-functional drug development teams from early research through clinical development.
Additional information
Compensation decisions are based on objective criteria including role responsibilities, experience/qualifications, internal equity, geographic location, and external market benchmarks.
Pay Range $166,738—$174,397 USD
Kiniksa does not accept unsolicited resumes from staffing agencies or search firms. Any resumes submitted without a signed agreement will be considered property of Kiniksa, and no fees will be paid.
About Kiniksa Pharmaceuticals
Kiniksa Pharmaceuticals is a commercial-stage biopharmaceutical company developing and commercializing novel therapies for diseases with unmet need, with a focus on cardiovascular indications.
With deep expertise in immunology and inflammation, Kiniksa is advancing a growing portfolio of approved and investigational medicines, anchored by its lead product, ARCALYST®, the first and only FDA-approved therapy for recurrent pericarditis. Grounded in rigorous science and bold innovation, the company fosters a highly collaborative, patient-first culture led by accomplished life sciences leaders.
At Kiniksa, talented individuals are trusted and empowered to make a real impact-shaping the future of medicine while improving the lives of patients who need it most.
Kiniksa is seeking a highly motivated Senior Scientist, In Vitro and In Vivo Pharmacology reporting to GVP, Research & Non-Clinical Development to join our Research organization. This individual will play a key role in advancing biologic drug candidates from discovery through clinical development by designing and executing in vitro and in vivo studies that characterize mechanism of action, target engagement, pharmacodynamic activity, and biomarker responses.
The successful candidate will serve as a scientific expert across multidisciplinary project teams and will contribute to the development of innovative therapies for immune-mediated and inflammatory diseases. Particular emphasis will be placed on the characterization of biologics, development of pharmacology assays, and understanding disease biology relevant to protease biology, inflammation, and immune dysregulation.
This is an ideal opportunity for a creative, hands-on scientist who thrives at the intersection of pharmacology, immunology, translational medicine, and therapeutic development. The role will collaborate closely with Clinical Development, Clinical Pharmacology, Bioanalysis, and CMC.
This role is based in our Lexington, MA office. Our office-based employees follow an onsite schedule of 5 days in the office (Mon-Fri)
Equal opportunity and legal notices
Kiniksa is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, transgender status, age, genetics, national origin, protected veteran status, or disability status, or any other legally protected category. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
From Kiniksa Pharmaceuticals's careers page, first listed on Rolev.ai on October 10, 2026. Rolev.ai is not the employer.
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Common questions
What is the salary for the Senior Scientist, In Vitro and In Vivo Pharmacology role at Kiniksa Pharmaceuticals?
The Senior Scientist, In Vitro and In Vivo Pharmacology posting at Kiniksa Pharmaceuticals states compensation of $166,738 – $174,397 per year. It is listed as a full-time position. Final pay may depend on location, experience, and interview evaluation on Kiniksa Pharmaceuticals's official career site.
Where is the Senior Scientist, In Vitro and In Vivo Pharmacology job at Kiniksa Pharmaceuticals located?
This Senior Scientist, In Vitro and In Vivo Pharmacology position at Kiniksa Pharmaceuticals is located in Lexington, MA (On-site). Always check Kiniksa Pharmaceuticals's application page for specific state eligibility or relocation policies.
What qualifications are required for Senior Scientist, In Vitro and In Vivo Pharmacology at Kiniksa Pharmaceuticals?
For the Senior Scientist, In Vitro and In Vivo Pharmacology role, Kiniksa Pharmaceuticals highlights 5+ years of relevant experience; a doctorate; experience with in vitro pharmacology, cell-based assays, pharmacodynamic assays, biologics characterization. Rolev.ai can score your existing resume against these requirements and show any skill gaps before you apply.
How do I apply for the Senior Scientist, In Vitro and In Vivo Pharmacology position at Kiniksa Pharmaceuticals?
This listing links directly to Kiniksa Pharmaceuticals's Greenhouse application page. You can apply directly on Kiniksa Pharmaceuticals's site, or use Rolev.ai to check your resume fit, generate a zero-hallucination tailored resume and cover letter for this posting, and autofill the Greenhouse application form in 1 click with the Rolev.ai Chrome extension. You always review the form and press Submit yourself.