(Senior) Scientist, Translational Biology

Company Summary

FL106 Inc. is a privately held, early-stage biotechnology company focused on developing novel drug delivery modalities. FL106 is backed by Flagship Pioneering, which provides the strategic vision and resources to advance FL106 from platform validation to clinical impact.

Position Summary

We are seeking a highly motivated and experienced Scientist to join our research team. The ideal candidate will have deep expertise in flow cytometry, primary cell isolation and sorting, microscopy and imaging, and gene-silencing techniques (siRNA), with in vivo/in vitro mouse experience. This role will contribute to the design and execution of preclinical studies to advance therapeutic programs.

Key Responsibilities

• Design, execute, and analyze complex in vitro / in vivo experiments to support research programs
• Lead and perform multi-parameter flow cytometry assays, including panel design, optimization, and data interpretation
• Perform and optimize primary cell isolation from tissues, including enzymatic and mechanical tissue dissociation, magnetic-activated cell sorting (MACS), and fluorescence-activated cell sorting (FACS), with attention to preserving cell viability, yield, native gene-expression signatures, and potential for further culture of the cells
• Perform and interpret microscopy-based assays, including high-content microscopy, immunofluorescence, confocal, and/or intravital imaging, to characterize cell and tissue phenotypes and validate target engagement
• Support mouse studies as needed, including disease models, dosing, tissue collection, and phenotypic analysis
• Develop and apply siRNA-based approaches for target validation and mechanistic studies
• Analyze and interpret data, generate reports, and present findings to cross-functional teams
• Collaborate with internal and external stakeholders to advance project goals
• Mentor junior scientists and contribute to a collaborative team environment
• Maintain accurate experimental records and ensure compliance with institutional and regulatory guidelines

Qualifications

• Ph.D. in Molecular Biology, Cell Biology, or a related field with 3-6+ years of relevant experience (industry preferred), or M.S. with significant experience
• Strong expertise in flow cytometry, including cell sorting (FACS), panel design, troubleshooting, and data analysis (e.g., FlowJo or similar tools)
• Hands-on experience with primary cell isolation techniques from mouse tissue, including tissue dissociation (enzymatic and mechanical), magnetic bead-based separation (MACS), and isolation of rare or fragile cell populations
• Hands-on experience with microscopy techniques (e.g., immunofluorescence, confocal microscopy) and associated image analysis software (e.g., ImageJ/Fiji, Imaris, or similar)
• Demonstrated experience with siRNA design, delivery, and functional validation
• Strong data analysis and problem-solving skills
• Excellent communication and presentation skills
• Ability to work independently and collaboratively in a fast-paced environment

Preferred Qualifications

• Experience with mouse models, including in vivo study design, dosing, and tissue collection
• Experience in translational or preclinical research environments
• Experience with cold-active or optimized dissociation protocols for isolating sensitive/rare cell types (e.g., podocytes, neurons, microglia) while minimizing dissociation-induced expression artifacts
• Experience with advanced imaging modalities (e.g., intravital microscopy, super-resolution, high-content imaging)
• Familiarity with additional molecular techniques (qPCR, Western blot, ELISA, RNA-seq, gene silencing, protein over-expression)
• Experience working in a biotech or pharmaceutical setting