Senior Software Engineer, AWS Cloud Infrastructure
- Pay
- $125,000 – $150,000 per year
- Location
- Remote (US)
- Job type
- Full-time
- Level
- Senior
- Listed
- 30 days ago
Skills & highlights for this role
- AWS
- Infrastructure as Code
- TypeScript
- Python
- IAM
- Kubernetes
Also useful
- Pulumi
- SST
- GitHub Actions
- Bitbucket Pipelines
About the role
Location: This position may be performed remotely, but requires the flexibility and willingness to travel as needed.
The Opportunity
You will own and shape how Praxis designs, governs, secures, and operates AWS at scale-from account structure and identity to the platforms and applications that run on them. You will be a hands-on builder, using your depth in cloud infrastructure and software engineering to create secure, reliable systems that enable our teams to move quickly.
You will work at the intersection of software engineering, cloud infrastructure, security, and operations. You will build and improve the systems that keep our teams moving fast while maintaining high standards for reliability, security, and compliance. You will work primarily in TypeScript and Python, use modern AI tooling as part of your daily engineering workflow, and take direct accountability for production operations, including on-call.
You will be expected to see problems, take ownership, and drive them through resolution. You will move quickly through incremental, well-controlled changes, question assumptions when there is a better path, and turn operational learnings into durable improvements. Just as importantly, you will raise the bar for the people and systems around you by sharing what you know, communicating clearly, and helping the broader team build and operate better.
Primary Responsibilities
- Own and evolve AWS architecture for enterprise workloads, including multi-account foundations, landing zone / Control Tower patterns, networking, security baselines, and shared platforms.
- Establish and continuously improve AWS governance, including organizational structure, SCPs, tagging, cost controls, compliance, audit readiness, and durable operational standards.
- Design and operate identity and access across AWS, including IAM, IAM Identity Center, and Microsoft Entra ID integrations for SSO, federation, role mapping, access reviews, and least-privilege access.
- Build, harden, and operate AWS platforms and full-stack services using TypeScript and Python, including compute, containers, serverless, data stores, messaging, and cloud automation as needed.
- Drive operational excellence across AWS platforms and workloads by building effective monitoring, alerting, dashboards, SLOs/SLIs, runbooks, incident response practices, and durable fixes to recurring problems; participate in the on-call rotation and own incidents through resolution and learning.
- Automate infrastructure and delivery through Infrastructure as Code-preferably Pulumi and/or SST-and CI/CD using Bitbucket Pipelines and/or GitHub Actions, with an emphasis on safe, incremental delivery and low blast radius.
- Partner across engineering and IT to translate needs into secure, maintainable solutions, improve production readiness and operational practices, mentor other engineers, and use sound judgment to move fast without breaking things.
Qualifications
- Senior-level software engineering experience, with substantial hands-on experience building and operating production systems on AWS.
- Strong full-stack engineering capability in TypeScript and Python, including APIs, services, tooling, and cloud automation.
- Deep experience with core AWS services used in enterprise environments, including IAM, Organizations, VPC, EC2, ECS/EKS or Lambda, S3, RDS/DynamoDB, CloudWatch, KMS, Config, and GuardDuty.
- Proven ability to design and operate AWS governance at scale, including multi-account strategy, policy guardrails, access control, security standards, and operational controls.
- Strong AWS networking fundamentals, including VPNs, peering, Transit Gateway, routing, DNS, and hybrid connectivity.
- Experience with enterprise SSO; Microsoft Entra ID (Azure AD) federation into AWS is strongly preferred, including SAML/OIDC, IAM Identity Center, application and role mapping, and access lifecycle practices.
- Experience working in regulated or audit-ready environments, with strong habits around change control, evidence and traceability, least privilege, and durable controls.
- Demonstrated operational ownership: able to establish meaningful alerts and monitors, reduce noise, improve reliability, respond to incidents, and turn operational learnings into engineering improvements.
- Strong Infrastructure as Code experience; Pulumi and/or SST strongly preferred. Terraform or AWS CDK experience is transferable and welcome.
- Experience with Bitbucket Pipelines and/or GitHub Actions.
- Proficient with modern AI coding and productivity tools, with the judgment to validate outputs, test changes, manage risk, and maintain production quality.
- The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement. You'll need comfort with screen work, basic hand coordination, and focus. Reasonable accommodations may be made to enable individuals with disabilities to perform these functions.
Pay and benefits
Annualized Base Salary $125,000—$150,000 USD
Compensation & Benefits
- At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive.
- This includes 99% of the premium paid for medical, dental and vision plans.
- We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage.
- Thinking about the future?
- We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP.
- We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns.
- Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring.
- We aim high, collaborate hard, and produce results.
Let's achieve the impossible together!
Diversity, Equity & Inclusion
Attention: Job Scam Alert
Praxis has recently become aware of fraudulent job recruitment postings from individuals claiming to represent Praxis. These postings seek financial information in connection with fraudulent opportunities for employment. If you suspect any fraudulent activity or misrepresentation in connection with a Praxis job opportunity, please report it to.
Praxis does not accept unsolicited submissions from recruitment agencies for open positions. We ask all recruitment agencies to refrain from contacting any Praxis employee regarding any position. All unsolicited resumes submitted by recruitment agencies to any Praxis employee in any form or method will be deemed to be the property of Praxis, and Praxis explicitly reserves the right to hire those candidate(s) without any financial obligation to the recruitment agency.
Company Overview
Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members.
Equal opportunity and legal notices
Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.
From Praxis Precision Medicines, Inc.'s careers page, first listed on Rolev.ai on October 10, 2026. Rolev.ai is not the employer.
How Rolev.ai helps with this application
Rolev.ai is a job search and application tool for US job seekers. For this Senior Software Engineer, AWS Cloud Infrastructure role at Praxis Precision Medicines, Inc., it shows how your resume fits, tailors your resume to the posting, and prepares the application for you to review.
See how you fit
Openings from employer career sites are ranked against your whole resume—and searchable inside Claude, ChatGPT, and Cursor via Rolev.ai MCP.
Tailor without inventing
Every change to your resume is checked against your original. New experience goes in only with your yes—zero fabricated claims.
Draft the full kit
Tailored and Full Match resumes, role-specific cover letters, and answers to employer screening questions are prepared in seconds.
1-Click Extension Autofill
The Chrome extension fills the employer's Greenhouse, Workday, Lever, or Ashby form in 1 click. You review it and press Submit.
Similar roles
All Software Developer jobs- Software DeveloperAccenture Federal Services · Washington, DC · $97.5k – $115k/yr
- Software Developer 803Freedom Technology Solutions Group · Annapolis Junction, MD · $150k – $200k/yr
- Software DeveloperPurvis Systems · Newport, RI
- NASA Human Spaceflight Artificial Intelligence (AI) Software Engineer and Data ScientistCACI · Houston, TX
- Senior Manager Software EngineeringNasdaq · Atlanta, GA
- Software Engineering Supervisor - Test SystemsMoog · Torrance, CA
Common questions
What is the salary for the Senior Software Engineer, AWS Cloud Infrastructure role at Praxis Precision Medicines, Inc.?
The Senior Software Engineer, AWS Cloud Infrastructure posting at Praxis Precision Medicines, Inc. states compensation of $125,000 – $150,000 per year. It is listed as a full-time position. Final pay may depend on location, experience, and interview evaluation on Praxis Precision Medicines, Inc.'s official career site.
Where is the Senior Software Engineer, AWS Cloud Infrastructure job at Praxis Precision Medicines, Inc. located?
Yes, this Senior Software Engineer, AWS Cloud Infrastructure opening at Praxis Precision Medicines, Inc. is listed as Remote (US). Always check Praxis Precision Medicines, Inc.'s application page for specific state eligibility or relocation policies.
What qualifications are required for Senior Software Engineer, AWS Cloud Infrastructure at Praxis Precision Medicines, Inc.?
For the Senior Software Engineer, AWS Cloud Infrastructure role, Praxis Precision Medicines, Inc. highlights experience with AWS, Infrastructure as Code, TypeScript, Python, IAM, Kubernetes. Rolev.ai can score your existing resume against these requirements and show any skill gaps before you apply.
How do I apply for the Senior Software Engineer, AWS Cloud Infrastructure position at Praxis Precision Medicines, Inc.?
This listing links directly to Praxis Precision Medicines, Inc.'s Greenhouse application page. You can apply directly on Praxis Precision Medicines, Inc.'s site, or use Rolev.ai to check your resume fit, generate a zero-hallucination tailored resume and cover letter for this posting, and autofill the Greenhouse application form in 1 click with the Rolev.ai Chrome extension. You always review the form and press Submit yourself.