Senior / Staff Cloud Platform Engineer (ML)
- Pay
- $220,000 – $290,000 per year
- Location
- South San Francisco, CA
- Listed
- Today
Position Description
Calico seeks a Senior / Staff Cloud Engineer to lead the execution and operation of our next-generation machine learning (ML) platform. As the technical authority for our Google Cloud Platform (GCP) environment, you will build infrastructure-as-Code (IaC), design secure perimeters, automate identity management, and migrate existing workflows into a unified, compliant infrastructure.
If you are passionate about DevSecOps, IaC, and building "paved paths" that empower scientists while enforcing rigorous security, this is the role for you. You will be the critical bridge that allows our ML Systems and Research engineers to train and deploy ML models for frontier BioML research.
Please note: No biology or life sciences background is required for this role.
Position Responsibilities
You will work with a team of researchers and engineers on Calico's key strategic cross-functional initiatives through the following responsibilities:
- Foundational Impact:
- Deliver our next-generation ML platform
- Lead the consolidation and modernization of our compute environments, and accelerate the whole company's R&D cycle
- GCP Foundation:
- Lead the centralization of GCP projects into a unified, compliant landing zone
- Design secure perimeters to protect sensitive biological data, and build automated guardrails using Terraform
- GKE Cluster Administration:
- Design, deploy, and maintain robust GKE clusters tailored for distributed ML training and batch processing workloads
- Troubleshoot node-level GPU/TPU issues, manage scheduling add-ons, and optimize cluster autoscaling
- Developer Experience & Onboarding:
- Design intuitive onboarding processes and "paved paths" for scientists to seamlessly onboard onto the new platform
- FinOps:
- Manage org-level GPU/TPU compute capacity, implement centralized billing and cost reporting, and build comprehensive monitoring dashboards to track cluster utilization and optimize R&D expenditure
Position Requirements
- BS/MS with 7+ years or PhD with 4+ years of relevant software engineering, DevSecOps, or Cloud architecture experience
- Strong programming skills in Python
- Strong hands-on experience with Google Cloud Platform (GCP) core services
- Experience with Kubernetes cluster administration
- Experience with Terraform, building CI/CD pipelines, and containerization (Docker)
- Must be willing to work onsite at least four days a week
Nice to Have
- A strong intellectual curiosity for life sciences
- Experience managing Kubernetes for HPC or ML workloads
- Experience supporting Machine Learning orchestration and queueing frameworks (e.g., Kueue, Ray)
- Experience reading and debugging ML Python code
- Experience implementing compliant cloud architectures (e.g., SOC2, HIPAA, or similar frameworks)
- Familiarity with Golang
- Strong communication skills with a proven ability to guide users through migration
Pay and benefits
The estimated base salary range for this role is $220,000 - $290,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.
Who We Are
Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico's highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.
From Calico Life Sciences's careers page, first listed on Rolev.ai on November 12, 2026. Rolev.ai is not the employer.
How Rolev.ai helps with this application
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Common questions
What is the salary for the Senior / Staff Cloud Platform Engineer (ML) role at Calico Life Sciences?
The Senior / Staff Cloud Platform Engineer (ML) posting at Calico Life Sciences states compensation of $220,000 – $290,000 per year. Final pay may depend on location, experience, and interview evaluation on Calico Life Sciences's official career site.
Where is the Senior / Staff Cloud Platform Engineer (ML) job at Calico Life Sciences located?
This Senior / Staff Cloud Platform Engineer (ML) position at Calico Life Sciences is located in South San Francisco, CA. Always check Calico Life Sciences's application page for specific state eligibility or relocation policies.
How do I apply for the Senior / Staff Cloud Platform Engineer (ML) position at Calico Life Sciences?
This listing links directly to Calico Life Sciences's Greenhouse application page. You can apply directly on Calico Life Sciences's site, or use Rolev.ai to check your resume fit, generate a zero-hallucination tailored resume and cover letter for this posting, and autofill the Greenhouse application form in 1 click with the Rolev.ai Chrome extension. You always review the form and press Submit yourself.