Personalis
Healthcare & Life SciencesDirect Greenhouse career site

Sr. Software Engineer, Clinical Software

Pay
$150,000 – $175,000 per year
Location
Fremont, CA · Hybrid
Job type
Full-time
Level
Senior
Experience
5+ years
Education
Bachelor's degree
Listed
30 days ago

Skills & highlights for this role

  • Python
  • AWS
  • relational databases

Also useful

  • Flask
  • FastAPI
  • Docker
  • React

Stated benefits & perks

  • Medical
  • Dental
  • Vision
  • 401k match
  • Tuition

Summary

We are seeking a Sr. Software Engineer to design, develop, and maintain our Laboratory Information Management Systems (LIMS). This role is a key contributor to our engineering team, taking ownership of feature development for both existing systems and new cloud-based platforms. You will work with senior engineers to tackle complex problems and deliver high-quality, scalable solutions that power our laboratory operations in a regulated environment.

Onsite: Monday, Tuesday, and Thursday

Responsibilities

  • Design, develop, test, and maintain software systems and features supporting laboratory operations.
  • Develop and optimize backend services and APIs using Python and/or Java.
  • Implement solutions using a variety of database technologies, including relational and graph databases.
  • Take ownership of deploying and maintaining services in our AWS cloud environment.
  • Actively participate in code reviews, design discussions, and technical documentation to ensure quality and maintainability.
  • Troubleshoot and resolve complex technical issues in development and production environments.
  • Collaborate with cross-functional teams to translate business requirements into robust technical solutions.

Qualifications

  • B.S. degree in Computer Science, Engineering, or a related technical field.
  • 5 years of professional software development experience.
  • Strong proficiency in at least one programming language such as Python or Java.
  • Proven experience building and deploying applications on AWS.
  • Solid experience with relational databases (e.g., PostgreSQL, MySQL) and developing REST APIs.
  • Experience with version control systems (e.g., Github, Bitbucket) and CI/CD concepts.
  • Excellent problem-solving skills and the ability to work independently on complex tasks.

Preferred

  • Experience with web frameworks like Flask or FastAPI.
  • Familiarity with modern JavaScript frameworks (e.g., React, Angular, or Vue.js).
  • Experience in the life sciences, healthcare, or another regulated industry.
  • Familiarity with containerization technologies (e.g., Docker).
  • Exposure to graph databases or NoSQL technologies.

What You'll Gain

  • Opportunity to take ownership of significant features and projects from design to deployment.
  • Deepen your expertise in AWS services and cloud architecture.
  • Gain valuable experience working in a regulated life sciences environment.
  • Clear pathways for career growth into a senior engineering role through mentorship and impactful work.

Pay and benefits

The hiring range for this position is $150,000 to $175,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.)

#LI-KK1 #LI-Hybrid

About Personalis

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time.

Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

Read the original posting

From Personalis's careers page, first listed on Rolev.ai on October 10, 2026. Rolev.ai is not the employer.

How Rolev.ai helps with this application

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Common questions

What is the salary for the Sr. Software Engineer, Clinical Software role at Personalis?

The Sr. Software Engineer, Clinical Software posting at Personalis states compensation of $150,000 – $175,000 per year. It is listed as a full-time position. Final pay may depend on location, experience, and interview evaluation on Personalis's official career site.

Where is the Sr. Software Engineer, Clinical Software job at Personalis located?

This Sr. Software Engineer, Clinical Software position at Personalis is located in Fremont, CA (Hybrid). Always check Personalis's application page for specific state eligibility or relocation policies.

What qualifications are required for Sr. Software Engineer, Clinical Software at Personalis?

For the Sr. Software Engineer, Clinical Software role, Personalis highlights 5+ years of relevant experience; a bachelor's degree; experience with Python, AWS, relational databases. Rolev.ai can score your existing resume against these requirements and show any skill gaps before you apply.

How do I apply for the Sr. Software Engineer, Clinical Software position at Personalis?

This listing links directly to Personalis's Greenhouse application page. You can apply directly on Personalis's site, or use Rolev.ai to check your resume fit, generate a zero-hallucination tailored resume and cover letter for this posting, and autofill the Greenhouse application form in 1 click with the Rolev.ai Chrome extension. You always review the form and press Submit yourself.