Apriori Bio: Protein Science Co-Op

About the role

This position is open exclusively to current Northeastern University Co-Op students.

Work Period: January 2027 to June 2027. This is a full-time, 40 hours per week position with 5 days in office.

Join Our Innovative Team at Apriori Bio!

Are you ready to be part of a pioneering biotech company on the frontline of developing solutions against rapidly evolving viruses like influenza and SARS-CoV-2? At Apriori Bio, we're creating a safer world through resilient vaccines and advanced antibody therapeutics using our cutting-edge Octavia™ platform.

Flagship Pioneering Co-Op Program

Welcome to the Flagship Pioneering Co-Op Program for the cohort dreaming big and taking courageous leaps. You'll join fellow peers across our ecosystem of companies and learn firsthand how we build first-in-category companies. You'll have access to enrichment sessions, a dedicated professional development track, and a mentor that help guide you toward your next step. By the end, you will carry on a meaningful project outcome, a genuine network, and a front-row view of how Flagship pioneers new ventures that change the world.

The Role

As a member of our protein science team, you'll help turn computationally designed vaccine immunogens into well-characterized proteins. Our team produces antigens in multiple formats for antigen validation and in-vivo studies, and develops the assays used to characterize and functionally validate them.

We're Looking For

• Highly motivated and enthusiastic co-op students for a six-month position, eager to dive into hands-on protein science.
• Individuals with a background in biochemistry, molecular biology, or bioengineering and a desire to master protein expression, purification, and characterization.

What You'll Do

• Express recombinant vaccine antigens and antibodies in mammalian expression systems, including small-scale transient transfection and scale-up.
• Purify proteins using affinity and size-exclusion chromatography on ÄKTA systems.
• Characterize protein quality and stability using SDS-PAGE, analytical SEC, and thermal stability methods such as DSF.
• Contribute to the development and execution of binding and functional assays, including ELISA and bio-layer interferometry (BLI), to assess antigenicity against panels of monoclonal antibodies.
• Document experiments in our electronic lab notebook (Benchling) and present results at team meetings.

Qualifications

• Pursuing a BS or MS in Biochemistry, Bioengineering, Chemical Engineering, Molecular Biology, or a related field
• Hands-on laboratory experience (coursework or research), such as SDS-PAGE, solution preparation, and accurate pipetting
• Experience with mammalian cell culture and aseptic technique
• Preferred: exposure to protein purification/chromatography or plate-based assays such as ELISA
• Strong organizational, record-keeping, and communication skills

What We Offer

• Build alongside founders. You'll work inside the same hypothesis-driven process Flagship uses to conceive and launch first-in-category companies.
• This can be the start of a longer story. Strong co-ops are considered for future opportunities across Flagship and its portfolio companies, not just for this one role.
• Work alongside people who left the safe path. Your colleagues are scientists, engineers, and operators who chose to build something new rather than join something already established.
• Take on real ownership. You're contributing to a venture that is still being defined. Your work can shape real decisions, not just support them.
• Be paid like the contributor you are. Compensation reflects the real work you take on.

• The pay range for this role is $25-$35 per hour.
• This role is a short-term engagement that is not eligible for health and welfare benefits.
• Retirement benefits may be available after completing a set number of hours.
• Compensation and benefits information is based on Apriori Bio's good faith estimate as of the date of publication and may be modified in the future.