Principal Engineer, Microsoft 365 and Copilot Platforms

General Summary

The Principal Engineer, Microsoft 365 and Copilot Platforms serves as the execution-focused technical lead for Microsoft 365 Modern Work and enterprise AI capabilities. This role translates business demand into secure, governed, supportable outcomes.

The ideal candidate provides technical leadership across Microsoft Teams, SharePoint Online, OneDrive, Exchange with deep specialization in Microsoft Copilot, GitHub Copilot, Copilot Studio, agents, and AI governance. The role balances approximately 60% hands on work with 40% technical leadership.

Key Duties and Responsibilities

• Own Technical Delivery: Lead Modern Work and AI initiatives, technical design, change control, implementation, working with our operations team.
• Lead business escalations, Critical incident management, root cause analysis and troubleshooting.
• Lead Microsoft Copilot and AI Enablement:
• Copilot - SharePoint agents, Cowork
• Copilot Studio - Power Automate, Power Apps
• GitHub & GitHub Copilot
• Drive automation and continuous improvement across platforms.
• Act as the technical authority for the team by challenging solution design, coordinating working sessions, and engaging with stakeholders across the business and driving solutions
• Create and maintain environment documentations, SOP, KB articles for supported technologies

Knowledge and Skills

• Broad Microsoft 365 Expertise: Principal- or Lead-level knowledge across Microsoft Teams, SharePoint Online, OneDrive, Exchange, Microsoft 365 governance, and related Entra ID, security, and compliance dependencies.
• Deep practical knowledge of Microsoft Copilot, Copilot Studio, Power Automate and Power Apps, agents, AI governance, and enterprise adoption controls - Agent 365.
• Demonstrated ability to convert broad objectives and business requirements into secure technical designs and completed delivery outcomes.
• Ability to balance business enablement, user experience and operational sustainability in a regulated enterprise environment.
• Experience leading complex technical escalations and coordinating execution across internal teams, control functions, vendors, and managed service providers.
• Excellent written and verbal communication skills, including the ability to explain technical decisions, risks, and recommendations to technical and non-technical audiences.
• Strong analytical and problem-solving skills, with comfort operating through ambiguity, incomplete information, shifting priorities, and multiple dependencies.

Education and Experience

• Bachelor's degree (or equivalent degree) in Information Systems, Computer Science, Engineering, Business, or a related discipline, or equivalent professional experience.
• Extensive experience delivering and governing enterprise Microsoft 365 Modern Work capabilities, including ownership of complex technical delivery, operational escalations, and cross-functional implementation.
• Experience implementing Microsoft Copilot, Copilot Studio, enterprise agents, AI governance, or related AI productivity capabilities is strongly preferred.
• Experience working in a regulated enterprise environment and partnering with security, privacy, legal, compliance, identity, and operational teams is strongly preferred.

#LI-HYBRID

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range

$144,000 - $216,000

Disclosure Statement

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation: Hybrid-Eligible Or On-Site Eligible

In this Hybrid-Eligible role, you can choose to be designated as

• Hybrid: work remotely up to two days per week; or select
• On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Hybrid

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at