Scientist, Metabolism
- Pay
- $130,000 – $165,000 per year
- Location
- South San Francisco, CA · On-site
- Job type
- Full-time
- Level
- Mid-level
- Experience
- 5+ years
- Education
- Doctorate
- Listed
- 31 days ago
Skills & highlights for this role
- primary liver cell isolation
- mouse models of liver disease
- viral vector and nucleic acid delivery
- in vivo functional assays
Also useful
- single cell genomics
- CRISPR pooled screening
- Perturb-seq
Stated benefits & perks
- Health
- Dental
- Vision
- 401k match
- Paid parental leave
Company info
NewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.
About the role
NewLimit is seeking an scientist with experience in liver biology and metabolism to join our Metabolism team. Our Metabolism team is developing reprogramming medicines to restore youthful function in aged hepatocytes in the context of metabolic disease. In this role, you will develop and perform assays for hepatocyte function, contribute to team decision making, and serve as a subject matter expert within NewLimit to enable our therapeutic development efforts.
Requirements
- Ph.D. in cell biology, molecular biology, biochemistry or a related field or equivalent industry experience (5+ years)
- Experience with primary liver cell isolation and functional characterization
- Experience working with mouse models of liver dysfunction
- Experience with transgenic manipulation of liver cells either ex vivo or in vivo (e.g. using viral vectors, nucleic acid delivery)
- Exceptional organizational skills, including detailed experimental record-keeping and the ability to manage multiple concurrent project
Nice to have
- History of contributing to a drug development program at the pre-clinical or clinical development stage
- Experience leading the design and execution of pre-clinical studies in mouse models
- Experience with single cell genomics methods
- Experience with pooled screening approaches using bulk or single cell read-outs (e.g. CRISPR fitness screens, Perturb/CROP-seq)
Benefits
NewLimit offers generous benefits to ensure our team can focus on our mission:
- Health, dental, and vision insurance
- 401(k) with company match
- Paid parental leave
- Industry-leading paid time off (PTO) - 20 days/year for all employees + holidays
- Meals and snacks on-site
Salary Range
$130,000 to $165,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience.
*This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future
As a Scientist on our team, you will
- Collaborate with our Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test epigenetic reprogramming interventions for aged and diseased hepatocytes
- Develop assays to preclinical models of liver disease to measure hepatocyte function
- Evaluate epigenetic reprogramming payloads using in vivo functional assays to select therapeutic candidates
- Deliver epigenetic reprogramming perturbations to hepatocytes in vivo using multiple transgenic manipulation methods (e.g. viral vectors, lipid nanoparticles)
- Analyze and interpret experimental data to drive pre-clinical decision making
From NewLimit's careers page, first listed on Rolev.ai on October 10, 2026. Rolev.ai is not the employer.
How Rolev.ai helps with this application
Rolev.ai is a job search and application tool for US job seekers. For this Scientist, Metabolism role at NewLimit, it shows how your resume fits, tailors your resume to the posting, and prepares the application for you to review.
See how you fit
Openings from employer career sites are ranked against your whole resume—and searchable inside Claude, ChatGPT, and Cursor via Rolev.ai MCP.
Tailor without inventing
Every change to your resume is checked against your original. New experience goes in only with your yes—zero fabricated claims.
Draft the full kit
Tailored and Full Match resumes, role-specific cover letters, and answers to employer screening questions are prepared in seconds.
1-Click Extension Autofill
The Chrome extension fills the employer's Greenhouse, Workday, Lever, or Ashby form in 1 click. You review it and press Submit.
Similar roles
- Associate Director, Immunobiology Open InnovationBiibhr · San Francisco, CA
- Cell-Based Testing ScientistEurofins · Lexington, MA · $29 – $34/hr
- Scientist 3, Biochemical and Cellular PharmacologyRoche · South San Francisco, CA · $103k – $192k/yr
- Scientist II, Biopharmaceuticals (GMP)Thermofisher · Middleton, WI
- Raven StealthCo - Scientist/Senior Scientist, Biology and PharmacologyRaven · Boston, MA
- Associate Scientist- Kumar LaboratorySt. Jude · Memphis, TN
More at NewLimit
All NewLimit jobsCommon questions
What is the salary for the Scientist, Metabolism role at NewLimit?
The Scientist, Metabolism posting at NewLimit states compensation of $130,000 – $165,000 per year. It is listed as a full-time position. Final pay may depend on location, experience, and interview evaluation on NewLimit's official career site.
Where is the Scientist, Metabolism job at NewLimit located?
This Scientist, Metabolism position at NewLimit is located in South San Francisco, CA (On-site). Always check NewLimit's application page for specific state eligibility or relocation policies.
What qualifications are required for Scientist, Metabolism at NewLimit?
For the Scientist, Metabolism role, NewLimit highlights 5+ years of relevant experience; a doctorate; experience with primary liver cell isolation, mouse models of liver disease, viral vector and nucleic acid delivery, in vivo functional assays. Rolev.ai can score your existing resume against these requirements and show any skill gaps before you apply.
How do I apply for the Scientist, Metabolism position at NewLimit?
This listing links directly to NewLimit's Greenhouse application page. You can apply directly on NewLimit's site, or use Rolev.ai to check your resume fit, generate a zero-hallucination tailored resume and cover letter for this posting, and autofill the Greenhouse application form in 1 click with the Rolev.ai Chrome extension. You always review the form and press Submit yourself.