Scientist/Senior Scientist, Immunology

Position

NewLimit is seeking a highly motivated Scientist/Senior Scientist in Immunology to lead and execute key discovery-to-preclinical research efforts in inflammatory and autoimmune diseases, with a strong emphasis on T cell and regulatory T cell (Treg) biology. This role will design and implement in vitro screening assays to support lead selection and contribute to preclinical efficacy, safety, and mechanism-of-action studies. You will work closely with cross-functional partners to support program advancement toward IND-enabling studies.

In your role as a Scientist, you will

• Collaborate with Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and evaluate epigenetic reprogramming interventions for aged T cells, including integration and interpretation of complex, multi-modal datasets
• Develop scalable functional assays in T cells and Tregs to predict therapeutic activity and inform lead selection
• Design and lead in vivo and in vitro immunology studies to support target discovery, validation, and preclinical development
• Contribute deep expertise in inflammatory and autoimmune disease biology to experimental design and data-driven program strategy
• Drive research in Treg biology, including differentiation, stability, and suppressive function
• Author or contribute to study reports, internal data packages, and regulatory-supporting documentation
• Mentor junior scientists and foster a collaborative, rigorous scientific culture
• Present data, analyses, and scientific recommendations clearly to internal teams and leadership

Requirements

• Ph.D. in immunology, cell biology, or a related field or BS/MS with 6+ years of relevant industry experience
• Hands-on experience with multi-parameter flow cytometry
• Experience designing in vivo models of autoimmune or inflammatory disease
• Experience with primary immune cell isolation, ex vivo culture, and Treg functional assay

Nice to have

• Experience with pooled in vitro or in vivo screening approaches using bulk or single-cell readouts (e.g., CRISPR fitness screens, Perturb-seq, CROP-seq)
• Experience with rheumatoid arthritis and/or colitis models
• Experience authoring IND-supporting study reports
• Experience managing or partnering with CROs to support preclinical studies, including alignment on study design, timelines, and data quality
• Familiarity with basic computational tools for data analysis (e.g., Python, R)

Benefits

NewLimit offers generous benefits to ensure our team can focus on our mission:

• Health, dental, and vision insurance
• 401(k) with company match
• Paid parental leave
• Industry-leading paid time off (PTO) - 20 days/year for all employees + holidays
• Meals and snacks on-site

Salary Range

$130,000 to $180,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO.